Caroll A. Co

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BACKGROUND Potential associations between background environmental chemical exposures and autoimmunity are understudied. OBJECTIVES Our exploratory study investigated exposure to individual environmental chemicals and selected mixtures in relation to the presence of antinuclear antibodies (ANA), a widely used biomarker of autoimmunity, in a representative(More)
RATIONALE Inhaled endotoxin induces airway inflammation and is an established risk factor for asthma. The 2005-2006 National Health and Nutrition Examination Survey included measures of endotoxin and allergens in homes as well as specific IgE to inhalant allergens. OBJECTIVES To understand the relationships between endotoxin exposure, asthma outcomes, and(More)
BACKGROUND Modern toxicology is shifting from an observational to a mechanistic science. As part of this shift, high-throughput toxicity assays are being developed using alternative, nonmammalian species to prioritize chemicals and develop prediction models of human toxicity. METHODS The nematode Caenorhabditis elegans (C. elegans) was used to screen the(More)
With the phasing-out of the polybrominated diphenyl ether (PBDE) flame retardants due to concerns regarding their potential developmental toxicity, the use of replacement compounds such as organophosphate flame retardants (OPFRs) has increased. Limited toxicity data are currently available to estimate the potential adverse health effects of the OPFRs. The(More)
OBJECTIVE Recent studies suggest antinuclear antibodies (ANA) may be related to mortality risk, but evidence is sparse and inconclusive. Thus, we investigated ANA associations with all-cause and cause-specific mortality in U.S. adults. METHODS Our sample included 3357 adults (ages ≥20 years) from the 1999-2004 National Health and Nutrition Examination(More)
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