Caroline Wroe

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It is well known that the greatest risk for mortality post-renal transplant is cardiovascular death. We compared a modified cardiac risk assessment system among renal transplant patients who subsequently died versus the group that survived. There was a good correlation between the low, medium, and high scores with survival. The deceased group had(More)
Denys-Drash syndrome (DDS) is caused by heterozygous mutations of the Wilms’ tumour suppressor gene, WT1, characterised by early-onset diffuse mesangial sclerosis often associated with male pseudohermaphroditism and/or Wilms’ tumourigenesis. Previously, we reported that the Wt1 tmT396 allele induces DDS kidney disease in mice. In the present study(More)
The construction of a full-length clone of the avian coronavirus infectious bronchitis virus (IBV) defective RNA (D-RNA), CD-91 (9,080 nucleotides [Z. Penzes et al., Virology 203:286-293]), downstream of the bacteriophage T7 promoter is described. Electroporation of in vitro T7-transcribed CD-91 RNA into IBV helper virus-infected primary chick kidney cells(More)
vitamin C supplementation on oxidative stress and inflammation status in haemodialysis patients. Nephrol Dial Transplant 2005; 20: 1874–1879 2. You SA, Wang Q. Ferritin in atherosclerosis. Clin Chim Acta 2005; 357: 1–16 3. Puntarulo S. Iron, oxidative stress and human health. Mol Aspects Med 2005; 26: 299–312 4. Kletzmayr J, Horl WH. Iron overload and(More)
Deletion mutagenesis has been used to identify essential regions for rescue of coronavirus defective RNAs (D-RNAs). Using this technique on a cloned IBV D-RNA CD-91, we have identified a region potentially important in its rescue. Comparing the sequence of D-RNAs rescued with those not rescued we have deduced that a 72 base region corresponding to base(More)
Sir, European guidelines for long-term management of the transplant patients were published in your journal in 2002. Section IV.9.3 of these guidelines discusses post-transplant erythrocytosis [1]. It refers to the paper of Wickre et al. [2] and claims that: ‘One study in 53 polycythaemic transplant patients failed to find any increased incidence of(More)
A 37-year-old man presented to his GP in July 1987 complaining of a 1-month history of a blocked nose and oral ulceration. He had worked as a quarryman for several years, often in the same quarry as cases 2 and 3. During this time, he was exposed to dust from silicarich sandstone. A nasal biopsy showed ulceration consistent with Wegener’s granulomatosis. He(More)
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