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Critical loss of CBP/p300 histone acetylase activity by caspase‐6 during neurodegeneration
By altering chromatin structure, histone acetyltransferases (HATs) act as transcriptional regulators. We observed in a model of primary neurons that histone acetylation levels decreased at the onsetExpand
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The pRb/E2F cell-cycle pathway mediates cell death in Parkinson's disease
The mechanisms leading to degeneration of dopaminergic neurons (DNs) in the substantia nigra of patients with Parkinson's disease (PD) are not completely understood. Here, we show, in the postmortemExpand
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Toxic gain of function from mutant FUS protein is crucial to trigger cell autonomous motor neuron loss
FUS is an RNA‐binding protein involved in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Cytoplasmic FUS‐containing aggregates are often associated with concomitant loss ofExpand
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Sodium Valproate Exerts Neuroprotective Effects In Vivo through CREB-Binding Protein-Dependent Mechanisms But Does Not Improve Survival in an Amyotrophic Lateral Sclerosis Mouse Model
Amyotrophic lateral sclerosis (ALS) is characterized by motoneuron (MN) degeneration, generalized weakness, and muscle atrophy. The premature death of MNs is thought to be a determinant in the onsetExpand
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HP1α guides neuronal fate by timing E2F‐targeted genes silencing during terminal differentiation
A critical step of neuronal terminal differentiation is the permanent withdrawal from the cell cycle that requires the silencing of genes that drive mitosis. Here, we describe that the α isoform ofExpand
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Targeting CREB-binding protein (CBP) loss of function as a therapeutic strategy in neurological disorders.
Histone acetylation/deacetylation is a master regulation of gene expression. Among the enzymes involved in this process, the CREB-binding protein (CBP) displays important functions during centralExpand
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Nogo receptor antagonizes p75NTR-dependent motor neuron death
The Nogo-66 receptor (NgR) plays a critical role in restricting axon regeneration in the central nervous system. This inhibitory action is in part mediated by a neuronal receptor complex containingExpand
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Sp3 and Sp4 Transcription Factor Levels Are Increased in Brains of Patients with Alzheimer’s Disease
Background/Aims: Alzheimer’s disease (AD) is characterized by extracellular Aβ peptide deposition originating from amyloid precursor protein cleavage and intracellular neurofibrillary tanglesExpand
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Degeneration of serotonin neurons triggers spasticity in amyotrophic lateral sclerosis
Spasticity occurs in a wide range of neurological diseases, including neurodegenerative diseases, after trauma, and after stroke, and is characterized by increased reflexes leading to muscleExpand
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Dysregulation of chromatin remodelling complexes in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis is a fatal neurodegenerative disease with paralysis resulting from dysfunction and loss of motor neurons. A common neuropathological finding is attrition of motor neuronExpand
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