Caroline P Owen

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Both the mandibular condyle and the glenoid fossa remodel in response to changes in the dentition during life, although the precise relationship between teeth and joint is not clear. This study was undertaken to ascertain changes, if any, occurring in the glenoid fossae in skeletons with much tooth wear. In a collection of skulls from an excavation site on(More)
PURPOSE The purpose of this study was to compare the accuracy, required time, and potential advantages of rapid prototyping technology with traditional methods in the manufacture of wax patterns for two facial prostheses. MATERIALS AND METHODS Two clinical situations were investigated: the production of an auricular prosthesis and the duplication of an(More)
Hepatitis B and the acquired immunodeficiency syndrome are serious diseases because of their poor prognoses. The increasing awareness of the latter has highlighted the need for adequate precautions against cross contamination. However, the risk to dental personnel is still far higher from hepatitis B than it is from the human immunodeficiency virus, and the(More)
This study reports on the prevalence of temporomandibular joint dysfunction in a sample of fifty-one edentulous non-denture wearing individuals. In comparison with other studies using similar criteria, and considering the anomalous mandibular postures observed, this sample of patients appears to have a low prevalence of dysfunction. Loss of vertical(More)
Oestrone sulphatase is an important target in the fight against hormone-dependent breast cancer. In an effort to investigate the reported definitive pharmacophore for oestrone sulphatase and continue our search for potent inhibitors of this enzyme, we have undertaken extensive synthesis, biochemical evaluation and physicochemical property determination of a(More)
PURPOSE To investigate the feasibility of obtaining expert consensus on the prosthodontic principles to be followed when constructing complete dentures, so that any modifications to materials and methods would not sacrifice those principles--a philosophy known as "appropriatech." These principles would then comprise a Minimum Acceptable Protocol (MAP) for(More)
  • C P Owen
  • 2012
All-ceramic restorations are achieving increasing popularity, partly because of the aesthetic demands of patients, but also because their increasing ease of fabrication and longevity compare favourably with the traditional plastic restorations in posterior teeth. The parallel development of cementation materials and bonding techniques has also improved(More)
We report the results of our study into a series of simple phenyl and alkyl sulfamates and alkyl methanesulfonates as potential inhibitors of the enzyme estrone sulfatase (ES). The results of the study show that the substituted phenyl sulfamates are good irreversible inhibitors; the alkyl sulfamate compounds were found to lack inhibitory activity; whilst(More)
We report the initial results of our study into a series of simple 4'-O-sulfamoyl-4-biphenyl based compounds as novel inhibitors of the enzyme estrone sulfatase (ES). The results of the study show that these compounds are potent inhibitors, possessing greater inhibitory activity than COUMATE, but weaker inhibitory activity than EMATE or the tricyclic(More)
We report the initial results of our study into the use of a potential transition-state (TS) of the reaction catalysed by the enzyme estrone sulfatase (ES) in the design of a series of cyclic esters of 4-[(aminosulfonyl)oxy]benzoate as novel inhibitors of ES. The results of the study show that these compounds are some of the most potent inhibitors known(More)