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Hypoxia develops at sites of rapid cancer growth near sites of poorly organized vasculature. Heparin binding growth factors (HBGFs) support neoangiogenesis of tumors. We examined the effect of culturing bone-targeted, metastatic C4–2B prostate cancer cells and bone stromal derived HS27a cells under hypoxic conditions on expression of vascular endothelial(More)
PREPARATIONS of Averrhoa carambola (star fruit) have been used in an attempt to treat ailments of several different types both by bornohs (the Malay medicine men) and by traditional Chinese herbalists. Among these ailments for which star fruit preparations have been 'prescribed" are headache, vomiting, coughing and restlessness (Burkhill, 1935 : Woei,1970).(More)
Perlecan (Pln) is a major heparan sulfate proteoglycan (HSPG) of extracellular matrices and bone marrow stroma. Pln, via glycosaminoglycans in domains I and V, acts as a co-receptor for delivery of heparin binding growth factors (HBGFs) that support cancer growth and vascularization. Specifically, glycosaminoglycans bind HBGFs and activate HBGF receptors,(More)
HIP/RPL29 is a heparan sulfate (HS) binding protein with diverse activities including modulation of heparanase (HPSE) activity. We examined HIP/RPL29's ability to modulate actions of HS-binding growth factors (HBGFs) in angiogenesis. Between 1 and 2.5 microg/ml (ca. 60-150 nM), HIP/RPL29 inhibited HBGF-stimulated endothelial cell tube formation. Aortic(More)
The in vitro development of bovine corneal opacity induced by two anionic surfactants, sodium decyl sulphate (NaDS) and sodium lauryl sulphate (NaLS), was monitored using a simple, specially constructed instrument, the opacitometer. Results show clearly that NaDS was more potent, and acted more rapidly, than NaLS, an order of potency which has been shown by(More)
The ability of 8 surfactants and 5 industrial chemicals to induce bovine corneal opacity in vitro was investigated using a simple specially constructed instrument, the opacitometer. Concentration-effect curves were constructed for each agent. The relative extent to which the agents caused the development of corneal opacity in vitro correlated well with(More)
Incubation of isolated bovine cornea with the surfactants lauryl trimethylammonium bromide (LTAB), sodium lauryl sulphate (NaLS) or Tween 20 in contact only with the epithelium side (outside) of the cornea produced dose-related development of opacity. The order of efficacy was LTAB greater than NaLS greater than Tween 20. After incubation and opacity(More)
1 The mode of action of 2-n-propyl-4-p-tolylamino-1,2,3-benzotriazinium iodide (TnPBI), which induced contractures of frog rectus abdominis muscle, was investigated. 2 TnPBI caused contractures of frog rectus abdominis when the muscle had been depolarized with potassium chloride. 3 Experiments with TnPBI and caffeine in calcium-free Ringer suggested that(More)