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Respiratory pathology research is limited by the number of appropriate multicellular models suitable for studying mechanical properties and signaling pathways that are involved in airway responsiveness. In this study, the electrophysiological and pharmacomechanical properties of organ-cultured explants derived from normal guinea pig bronchi and trachea were(More)
Human cytochrome P-450 epoxygenase enzymes metabolize eicosapentaenoic acid (EPA), an omega-3-polyunsaturated fatty acid (PUFA), and leads to the production of 17(18)-epoxyeicosatetraenoic acid, or 17(18)-EpETE. The aim of the present study was to delineate the mode of action of 17(18)-EpETE on human pulmonary artery (HPA) and distal bronchi. Isometric(More)
INTRODUCTION About 1% of the general population are receiving systemic glucocorticoids. The information about this treatment sought by patients is unknown. MATERIALS AND METHODS The website www.cortisone-info.fr aims to provide therapeutic information about glucocorticoids and glucocorticoid therapy. It was posted on January 16, 2012. The information(More)
In free recall tasks, when low- and high-frequency items are mixed within the to-be-remembered lists, the usual recall advantage found for high-frequency words is eliminated or reversed. Recently, this mixed-list paradox has also been demonstrated for short-term serial recall (Hulme, Stuart, Brown, and Morin, 2003). Although a number of theoretical(More)
Is memory temporally organized? According to temporal distinctiveness models of memory, temporally isolated items should be better remembered than temporally crowded items in free recall tasks. Here, we tested this class of model by varying the temporal isolation of items either predictably (Experiment 1) or unpredictably (Experiment 2) in a free recall(More)
The use of multimodal (speech plus manual) control of the sensors on combinations of one, two, three or five simulated unmanned vehicles (UVs) is explored. Novice controllers of simulated UVs complete a series of target checking tasks. Two experiments compare speech and gamepad control for one, two, three or five UVs in a simulated environment. Increasing(More)
OBJECTIVE The only validated nausea and vomiting of pregnancy (NVP) severity index is the Motherisk Pregnancy-Unique Quantification of Emesis and Nausea (PUQE) index that covers symptoms in the previous 12 hours. We sought to assess the validity of a modified-PUQE index that covers the entire first trimester of pregnancy by comparing NVP severity scores(More)
OBJECTIVE To describe patterns of care for pediatric patients with advanced heart disease who experience in-hospital death. DESIGN Retrospective single-institution medical record review. SETTING A tertiary care pediatric hospital. PARTICIPANTS All patients younger than 21 years who died in the inpatient setting between January 1, 2007, and December(More)
The effects of a newly synthesized docosahexaenoic acid (DHA) derivative, CRBM-0244, on lung inflammation and airway hyperresponsiveness were determined in an in vitro model of TNF-α-stimulated human bronchi and in an in vivo model of allergic asthma. Mechanical tension measurements revealed that CRBM-0244 prevented bronchial hyperresponsiveness in(More)