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OBJECTIVES To evaluate the uptake and outcome of expectant management of spontaneous first trimester miscarriage in an early pregnancy assessment unit. PARTICIPANTS 1096 consecutive patients with a diagnosis of spontaneous first trimester miscarriage. METHODS Each miscarriage was classified as complete, incomplete, missed, or anembryonic on the basis of(More)
OBJECTIVE To determine whether elevation of a biological marker of inflammation would be a better predictor of bronchopulmonary dysplasia (BPD) development than lung function measurement results. DESIGN Prospective study. SETTING Tertiary neonatal intensive care unit. PATIENTS 78 prematurely born infants (median gestational age 29 (range 24-32) weeks)(More)
OBJECTIVE To determine whether prematurely born infants exposed to chorioamnionitis compared to those not exposed have poorer lung function and are more likely to develop severe bronchopulmonary dysplasia (BPD). DESIGN Results were analysed from consecutive infants born at <33 weeks gestation with placental histology results and lung function measurement(More)
BACKGROUND Acute vascular rejection (AVR) is characterized by vascular injury and systolic graft dysfunction and is often associated with elevated panel reactive antibodies (PRAs) to HLA antigens. Plasmapheresis has been shown to improve the otherwise poor prognosis of AVR, but its use is often complicated and limited by hypotension. METHODS AND RESULTS(More)
OBJECTIVE To determine if infants developing bronchopulmonary dysplasia (BPD), particularly mild BPD, initially had minimal lung function abnormalities, which then worsened throughout the neonatal period. DESIGN Prospective observational study. SETTING Tertiary neonatal intensive care unit. PATIENTS 74 infants with a median gestational age of 30 weeks(More)
Bronchopulmonary dysplasia (BPD) is associated with an early inflammatory response that persists after the first week of life. Inflammatory mediators can induce hemoxygenase-1 with a consequent increase in carbon monoxide (CO) production. End-tidal CO (ETCO) levels would be elevated in infants developing BPD. Serial measurements of ETCO levels were(More)
OBJECTIVES To determine whether chest radiograph (CXR) thoracic areas and lung volumes differed between infants who did and did not develop BPD and according to the severity of BPD developed. WORKING HYPOTHESIS Infants developing BPD, particularly if moderate or severe, would have low CXR thoracic areas and lung volumes in the perinatal period. STUDY(More)
OBJECTIVE To test the hypothesis that exhaled nitric oxide levels on day 28 and changes in exhaled nitric oxide levels in the neonatal period would differ according to whether infants developed bronchopulmonary dysplasia (BPD) and its severity. DESIGN Prospective observational study. SETTING Tertiary neonatal intensive care unit. PATIENTS 80 infants(More)
A system for the isolation of anaerobes based upon the use of reducible solid media is described. Plates of reducible media prepared and stored aerobically were reduced before use by incubation in a GasPak jar for 24 h. Clinical specimens for culture were carefully selected. The value of Amies transport medium was confirmed. Selective and nonselective(More)
INTRODUCTION Chronic oxygen dependency (COD) is a common adverse outcome of very premature birth. It is, therefore, important to develop an accurate and simple predictive test to facilitate targeting of interventions to prevent COD. Our aim was to determine if a simple score based on respiratory support requirements predicted COD development. METHODS A(More)