Caroline M. Moore

2Jan van der Meulen
1Marilena Loizidou
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  • Ian A. Donaldson, Roberto Alonzi, Dean Barratt, Eric Barret, Viktor Berge, Simon Bott +16 others
  • 2015
BACKGROUND Focal therapy as a treatment option for localized prostate cancer (PCa) is an increasingly popular and rapidly evolving field. OBJECTIVE To gather expert opinion on patient selection, interventions, and meaningful outcome measures for focal therapy in clinical practice and trial design. DESIGN, SETTING, AND PARTICIPANTS Fifteen experts in(More)
OBJECTIVE To quantitatively determine the prevalence of anxiety and depression in men on active surveillance (AS). DESIGN Cross-sectional questionnaire survey. SETTING Secondary care prostate cancer (PCa) clinics across South, Central and Western England. PARTICIPANTS 313 men from a total sample of 426 with a histological diagnosis of PCa currently(More)
OBJECTIVE To compare the diagnostic outcomes of the current approach of transrectal ultrasound (TRUS)-guided biopsy in men with suspected prostate cancer to an alternative approach using multiparametric MRI (mpMRI), followed by MRI-targeted biopsy if positive. DESIGN Clinical decision analysis was used to synthesise data from recently emerging evidence in(More)
Photochemical internalisation (PCI) is a technique for improving cellular delivery of certain bioactive agents which are prone to sequestration within endolysosomes. There is a wide range of agents suitable for PCI-based delivery including toxins, oligonucleotides, genes and immunoconjugates which demonstrates the versatility of this technique. The basic(More)
Statistical shape models of soft-tissue organ motion provide a useful means of imposing physical constraints on the displacements allowed during non-rigid image registration, and can be especially useful when registering sparse and/or noisy image data. In this paper, we describe a method for generating a subject-specific statistical shape model that(More)
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