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BACKGROUND This review was performed to test the hypothesis that presymptomatic diagnosis, for example by newborn screening, and early treatment may prevent or reduce irreversible organ damage and thereby improve outcome and quality of life in patients with cystic fibrosis. OBJECTIVES To determine whether there is evidence that early diagnosis of cystic(More)
An emerging infectious facial cancer threatens Tasmanian devils with extinction. The disease is likely to occur across the range of the devil within 5 years. This urgent time frame requires management options that can be implemented immediately: the establishment of insurance populations, in captivity, wild-living on islands, and aiming for eradication in(More)
1. Center for Evolutionary and Conservation Genetics, National Zoological Park, Washington, DC, 20008, USA 2. Australasia Regional Association of Zoological Parks and Aquariums, PO Box 20, Mosman NSW 2088, Australia 3. Alexander Center for Applied Population Biology, Lincoln Park Zoo, 2001 N. Clark St. Chicago, IL 60614, USA 4. Association of Zoos and(More)
An existing arterio-venous shunt thrombosis model in the rat has been modified to increase its usefulness for the testing of anti-thrombotic agents and characterised using morphological and radiometric techniques. The thrombus formed on the cotton thread held in the shunt was found to be composed of platelet aggregates surrounded by red thrombus. After 30(More)
An insurance population for the critically endangered Tasmanian devil was established in 2006. Due to successful captive breeding, the population has reached its carrying capacity of 600 devils and retains 99.95 % of founding gene diversity. Although reproduction has been quite successful, possible relatedness among founding individuals, influences of(More)
The role of thrombin in the formation of arterial thrombi is poorly understood. With the new availability of the specific thrombin inhibitor, recombinant desulphatohirudin, in large quantities this is now under investigation. A new model of arterial thrombosis in rats is described where a thrombus is formed on a mechanically injured vessel in vivo. Both(More)
There were slightly fewer than usual registrants but a cohesive, cosy conference ensued. Most participants travelled overland arriving on Monday night. The conference was opened by Tumu Te Heu Heu of Ngati Tuwharetoa. The Symposim that followed, on the theme 'Disturbance in New Zealand Ecosystems', produced a lot of material relevant to a conference held in(More)
BACKGROUND Sickle cell disease is an inherited disorder that occurs throughout the world with its highest incidence in areas of Africa where malaria is endemic. It affects up to one in 60 infants born in some areas of Africa. There are a number of potentially serious complications associated with the condition, and it is suggested that early treatment(More)
Cystic fibrosis (CF) is one of the commonest lethal inherited conditions among Caucasians. It affects multiple organ systems and exhibits a range of clinical problems of varying severity. Life expectancy has improved in recent years as treatment regimes have become more intensive, but current treatments are expensive, often time consuming and may affect(More)
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