Caroline L Poulter

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BACKGROUND Increased subchondral bone turnover may contribute to pain in osteoarthritis (OA). OBJECTIVES To investigate the analgesic potential of a modified version of osteoprotegerin (osteoprotegerin-Fc (OPG-Fc)) in the monosodium iodoacetate (MIA) model of OA pain. METHODS Male Sprague Dawley rats (140-260 g) were treated with either OPG-Fc (3 mg/kg,(More)
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