Learn More
The Drosophila trithorax group gene brahma (brm) encodes the ATPase subunit of a 2-MDa chromatin-remodeling complex. brm was identified in a screen for transcriptional activators of homeotic genes and subsequently shown to play a global role in transcription by RNA polymerase II. To gain insight into the targeting, function, and regulation of the BRM(More)
Chronic myeloid leukemia (CML) accounts for approximately 15% of adult leukemias. Forty percent of patients with CML are asymptomatic, in whom the disease is detected solely based on laboratory abnormalities. Since the introduction of tyrosine kinase inhibitor therapy in 2001, CML has become a chronic disease for the majority of patients. Primary care(More)
PURPOSE OF REVIEW Symptomatic pulmonary embolism is associated with significant morbidity and mortality, but whether the same is true of unsuspected pulmonary embolism (UPE) has only recently become the subject of clinical research. Interest in the impact of UPE on patient outcomes has emerged, as their detection has become more common with the standard use(More)
Autoimmune myelofibrosis (AIMF) is a distinct clinicopathological entity associated with diffuse bone marrow fibrosis and a benign clinical course. Distinction from neoplastic etiologies of marrow fibrosis, particularly primary myelofibrosis, is imperative, but few studies have documented histopathologic features in a large series. We describe 29 patients(More)
2563 Background: The purpose of our study was to compare how effectively RECIST 1.1 captures lymph node disease and treatment response in advanced prostate cancer compared to RECIST 1.0 based on "per lymph node" (LN) analysis Methods: 30 study group pts (med. 69 yrs, PSA 55.55 (0.06 - 2625) ng/ml, Gleason 8) are part of an ongoing prospective clinical(More)
Venous thromboembolism (VTE) is a major cause of morbidity and mortality among patients with cancer. Although much is known about the factors that contribute to VTE risk, pre-emptive therapy in high-risk populations is clearly indicated in only a few clinical situations. Low-molecular-weight heparin is still the recommended class of anticoagulants for(More)
PURPOSE To determine the maximal tolerated dose (MTD) of the combination of weekly temsirolimus and every other week vinorelbine in patients with advanced or refractory solid tumors. METHODS Patients were treated with intravenous temsirolimus on days 1, 8, 15, and 22 and intravenous vinorelbine on days 1 and 15. Cycles were repeated every 28 days. (More)
e15191 Background: CRPC remains a fatal disease but with improved survival based on the development of novel agents. These developments now allow for sequential therapies. We treated 20 patients in a phase II evaluation with Mitoxantrone (MTX) followed by docetaxel, estramustine, carboplatin (DEC). METHODS Pts with CRPC who progressed on or after prior(More)
e15196 Background: To evaluate the diagnostic utility of combined PET/CT imaging with 18F-NaF, 18F-FDG and circulating tumor cells (CTCs) in early detection and localization of metastatic disease in men with treated localized primary prostate cancer who present with biochemical failure (PSA relapse) and negative standard imaging tests. METHODS As part of(More)