Caroline Greene

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Interleukin-1 (IL-1) is a central regulator of the immune and inflammatory responses. Recently, significant advances have been made in the area of IL-1 receptors and IL-1 signal transduction. A family of proteins has been described that share significant homology in their signaling domains with the Type I IL-1 receptor (IL-1RI). These include the IL-1(More)
Interleukin-1 receptor-associated kinase, IRAK, has been shown to activate NFkappaB in response to interleukin-1. We have explored the involvement of IRAK in regulation of the interleukin-2 gene in the murine thymoma cell line EL4.NOB-1 by examining its effect on interleukin-2 promoter-linked reporter gene expression, interleukin-2 gene transcription and(More)
In chlorophyll-containing spores of Onoclea sensibilis, depletion of lipid reserves during germination is correlated with increases in the activity of the glyoxylate cycle enzymes isocitrate lyase and malate synthase. In Onoclea, the heterotrophic activity associated with lipid catabolism occurs at the same time that autotrophic activity is taking place.(More)
B. C. ABBOTT M. E. AVERY C. H. BAKER BRUNO BALKE D. E. BASS D. F. BOHR AREND BOUHUYS EUGENE BRAUNWALD R. W. BULLARD E. R. BUSKIRK C. A. CHIDSEY C. R. COLLIER BURTON COMBES J. 0. DAVIS R. P. DURBIN R. W. ECKSTEIN H. A. EDER CHARLES EDWARDS SYDNEY ELLIS J. N. FAIN L. E. FARHI A. P. GAGGE J. P. GILMORE H. M. GOODMAN F. J. HADDY N. S. HALMI R. J. HAVEL E. W.(More)
Delta-crystallin is directly related to argininosuccinate lyase (ASL), and catalyzes the reversible hydrolysis of argininosuccinate to arginine and fumarate. Two delta-crystallin isoforms exist in duck lenses, delta1 and delta2, which are 94% identical in amino acid sequence. Although the sequences of duck delta2-crystallin (ddeltac2) and duck(More)
Enzymes of the glyoxylate cycle, isocitrate lyase and malate synthase, are active during the germination of spores of the fern Dryopteris filix-mas. Increases in activity of both enzymes are correlated with the breakdown of lipid reserves. The occurrence of these enzymes suggests that the microbodies previously described in these spores are glyoxysomes.