Caroline Crocker

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Indirect-acting serotonin (5-HT) receptor agonists (e.g., selective 5-HT reuptake inhibitors [SSRI]) stimulate multiple 5-HT receptors, although the role of particular receptors as well as interaction(s) among different receptors in the therapeutic effects of SSRIs is not fully understood. Relatively few studies have systematically examined direct-acting(More)
In order to explore the potential oncostatic properties of the pineal hormone, melatonin, we have investigated its binding characteristics and functional effects in a human malignant melanoma (M-6) cell line. Binding studies in M-6 membranes showed the coexistence of 2-[125I]iodomelatonin binding sites with picomolar and nanomolar affinities. Guanine(More)
Since benzodiazepines (BZs) have been shown to inhibit the growth of some cell lines, the effects of these drugs on human melanoma (M-6) cell growth were examined. Cell growth was measured by the tetrazolium salt (MTT) assay or the Hoechst 33258 DNA assay. Diazepam, a non-selective BZ agonist, and Ro5-4864, a peripheral-type agonist, inhibited M-6 cell(More)
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