Caroline Crocker

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In order to explore the potential oncostatic properties of the pineal hormone, melatonin, we have investigated its binding characteristics and functional effects in a human malignant melanoma (M-6) cell line. Binding studies in M-6 membranes showed the coexistence of 2-[125I]iodomelatonin binding sites with picomolar and nanomolar affinities. Guanine(More)
Indirect-acting serotonin (5-HT) receptor agonists (e.g., selective 5-HT reuptake inhibitors [SSRI]) stimulate multiple 5-HT receptors, although the role of particular receptors as well as interaction(s) among different receptors in the therapeutic effects of SSRIs is not fully understood. Relatively few studies have systematically examined direct-acting(More)
Since benzodiazepines (BZs) have been shown to inhibit the growth of some cell lines, the effects of these drugs on human melanoma (M-6) cell growth were examined. Cell growth was measured by the tetrazolium salt (MTT) assay or the Hoechst 33258 DNA assay. Diazepam, a non-selective BZ agonist, and Ro5-4864, a peripheral-type agonist, inhibited M-6 cell(More)
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