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Analytic queueing network models often assume infinite capacity for all queues. For real systems this infinite capacity assumption does not hold, but is often maintained due to the difficulty of grasping the between-queue correlation structure present in finite capacity networks. This correlation structure helps explain bottleneck effects and spillbacks,(More)
Liquid chromatography-tandem mass spectrometry (LC-MS/MS) and multiple reaction monitoring mass spectrometry (MRM-MS) proteomics analyses were performed on eccrine sweat of healthy controls, and the results were compared with those from individuals diagnosed with schizophrenia (SZ). This is the first large scale study of the sweat proteome. First, we(More)
The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. This paper proposes a simulation-based optimization (SO) method that enables the efficient use of complex stochastic urban traffic simulators to address various transportation problems. It presents a metamodel that integrates information(More)
This paper uses a simulation-based optimization framework to investigate the added value of using higher-order distributional information from detailed traffic simulators to address signal control problems. In particular, this paper uses higher-order travel time distributional information to derive signal plans that account for travel time reliability. In(More)
This paper applies a computationally efficient simulation-based optimization (SO) algorithm suitable for large-scale transportation problems. The algorithm is based on a metamodel approach. The metamodel combines information from a high-resolution yet inefficient microscopic urban traffic simulator with information from a scalable and tractable analytical(More)
We propose a new Financial Condition Index (FCI) for Asian economies based on two different methodologies: a VAR model and a Dynamic Factor Model. The paper shows that this index has predictive power in forecasting GDP growth and may be thus used as a leading indicator. Based on the FCI, financial conditions in Asia tightened substantially earlier in the(More)
The MIT Faculty has made this article openly available. Please share how this access benefits you. Your story matters. Abstract Traditional queueing network models assume infinite queue capacities due to the complexity of capturing interactions between finite capacity queues. Accounting for this correlation can help explain how congestion propagates through(More)
In elderly population sepsis is one of the leading causes of intensive care unit (ICU) admissions in the United States. Sepsis-induced delirium (SID) is the most frequent cause of delirium in ICU (Martin et al., 2010). Together delirium and SID represent under-recognized public health problems which place an increasing financial burden on the US health care(More)