Carolina Miller-Pérez

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We report the existence and anatomical distribution to nociceptin/orphanin-FQ (N/O FQ)-like immunoreactivity in neurons and fibers in the perioesophageal ganglia of the snail (Helix aspersa). Intracellular recordings from perioesophageal ganglion neurons showed that the application of 10 microM N/O FQ produced an excitatory action in 22% of the neurons(More)
The neuropeptide nociceptin/orphanin FQ (N/OFQ) and its receptor are members of the endogenous opioid peptide family. In mammals N/OFQ modulates a variety of biological functions such as nociception, food intake, endocrine, control of neurotransmitter release, among others. In the molluscs Cepea nemoralis and Helix aspersa the administration of N/OFQ(More)
SUMMARY Chemical substances play an important role in life quality; they are present in household items and consumer products like furniture, cloths, toys, etc. However some of these substances could be dangerous for health and environment. Among the best known are the organohalogens pollutants like the polychlorinated biphenyls (PCBs) and polybrominated(More)
The role in nociception of nociceptin/orphanin FQ (N/OFQ) and its receptor, the opioid receptor-like 1 (NOP), remains unclear because this peptide has been implicated in both suppression and enhancement of nociception. The present work characterises the effects of N/OFQ and the NOP receptor antagonist, the pseudopeptide(More)
SUMMARY Clonation of opioid receptors δ, µ and κ was followed by identification and sequencing of and other member of the opioid family: the opioid receptor like-1 (ORL-1). Although they share similarities with receptors µ, δ and κ, endogenous opioid ligands like ß-endorphin, dynorphin A and enkephalins do not have great affinity for this receptor. After(More)
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