Carolina Arez Constant

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INTRODUCTION Tobacco smoke is a risk factor for Chronic Obstructive Pulmonary Disease and a major public health problem. Prenatal maternal smoking and post-natal environmental tobacco smoke (ETS) lead to dose-dependent decrease in lung function and respiratory morbidity. Influence of different socioeconomic indicators and ETS in the home has also been(More)
OBJECTIVES To assess the prevalence of respiratory disease in school-aged children and to determine the value of field spirometry. METHODS Data on 313 1st and 4th graders from four public schools in Lisbon were analyzed. A respiratory self-answered questionnaire and standard spirometry were performed. Descriptive and bivariate analysis was followed by(More)
BACKGROUND Type 1 Diabetes Mellitus (T1DM) is the most common endocrine-metabolic disease in children. It is associated with vascular and neuropathic complications, and may also affect growth and development. OBJECTIVE To correlate the metabolic control and disease duration with growth and puberty in patients with T1DM followed in a Pediatric(More)
BACKGROUND Two key limitations hamper intervention research in bronchiolitis: the absence of a clear definition of disease, and the heterogeneous choice of outcome measures in current clinical trials. We assessed how paediatricians and general practitioners (GPs) perceived definition and clinically important outcomes in bronchiolitis. METHODS A nationwide(More)
INTRODUCTION Advances in molecular diagnosis have made it possible to detect previously unknown viral agents as causative agents of lower respiratory tract infections (LRTI). The frequency and relevance of viral coinfections is still debatable. OBJECTIVE compare clinical presentation and severity between single virus infection and viral coinfection in(More)
In Western Europe, Portugal has the highest incidence of tuberculosis (TB) as well as HIV infection. At the Department of Infectious Diseases, Hospital de Santa Maria, Lisbon, we have observed a steady increase in cases of drug resistant (DR) and multi-drug resistant (MDR) TB over the last few years. To identify the determinants of drug- resistant(More)
Bacille Calmette-Guérin (BCG) vaccination is occasionally associated with lymphadenitis, called BCGitis, and only rarely can it occur in the setting of immunodeficiency. We report six cases of BCGitis admitted to our hospital (2005-7) for surgical treatment: five were male, in all cases BCG was given at birth; median age at presentation was 5.5 months.(More)
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