Carole Goebel

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UNLABELLED BACKGROUND; Motor function is deficient in many patients with obsessive-compulsive disorder (OCD), especially in the face. To investigate subtle motor dysfunction, kinematical analysis of emotional facial expressions can be used. Our aim was to investigate facial movements in response to humorous film stimuli in OCD patients. METHOD Kinematical(More)
We studied glucocorticoid receptor autoregulation and corticotropin response to dexamethasone in depressed patients and controls, attempting to control for the confounding effect of endogenous glucocorticoids. After depletion of endogenous cortisol, depressed patients showed an attenuated suppressibility of corticotropin by dexamethasone in the face of(More)
OBJECTIVE To compare the efficacy and safety of sertraline and amitriptyline in a German outpatient population. METHODS Patients with Major Depression (DSM-III-R) and HAM-D (21 items) > or = 21 in 19 German centers received double-blind treatment with sertraline (initial dose 50 mg, titration up to 100 mg) or amitriptyline (75 mg, up to 150 mg) over 6(More)
Abstract Autoregulation of receptor systems by their own ligands is a well established biological phenomenon. While down-regulation of the glucocorticoid binding capacity by glucocorticoids has been shown in animals and humans, data on up-regulation processes in humans are lacking. To further explore glucocorticoid receptor plasticity in relation to(More)
BACKGROUND Hypoxia and inflammation have been identified as hallmarks of cancer. A majority of hepatocellular carcinomas are preceded by hepatitis B- or C-related chronic infections suggesting that liver cancer development is promoted by an inflammatory microenvironment. The inflammatory cytokine oncostatin M (OSM) was shown to induce the expression of(More)
(2011) A size barrier limits protein diffusion at the cell surface to generate lipid-rich myelin-membrane sheets. (2011) Inhibition of myelin membrane sheath formation by oligodendrocyte-derived exosome-like vesicles. (2011) Role of macrophage migration inhibitory factor in primary glioblastoma multiforme cells. (2011) Sir-two-homolog 2 (Sirt2) modulates(More)
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