Learn More
The LASER Trial is an RCT of the effectiveness of the use of a Temperature-controlled Laminar Airflow (TLA) device in adults with severe allergic asthma. The trial is funded by the NIHR-HTA. The trial aims to determine whether home-based nocturnal treatment with a TLA device can reduce the frequency of asthma exacerbations over a one year period. In order(More)
BACKGROUND Asthma affects more than 5 million patients in the United Kingdom. Nearly 500,000 of these patients have severe asthma with severe symptoms and frequent exacerbations that are inadequately controlled with available treatments. The burden of severe asthma on the NHS is enormous, accounting for 80 % of the total asthma cost (£1 billion), with(More)
Background and study aims: Mucosal views can be impaired by residual bubbles and mucus during gastroscopy. This study aimed to determine whether a pre-gastroscopy drink containing simethicone and N-acetylcysteine improves mucosal visualisation. Patients and methods: We conducted a randomized controlled trial recruiting 126 subjects undergoing routine(More)
BACKGROUND Malignant pleural mesothelioma is an incurable cancer caused by exposure to asbestos. The United Kingdom has the highest death rate from mesothelioma in the world and this figure is increasing. Median survival is 8 to 12 months, and most patients have symptoms at diagnosis. The fittest patients may be offered chemotherapy with palliative intent.(More)
  • 1