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HSF-1 Regulators DDL-1/2 Link Insulin-like Signaling to Heat-Shock Responses and Modulation of Longevity

• Wei-Chung Chiang, Tsui-Ting Ching, Hee Chul Lee, Carol Mousigian, Ao-Lin Hsu
• Cell
• 2012

Extended longevity is often correlated with increased resistance against various stressors. Insulin/IGF-1-like signaling (IIS) is known to have a conserved role in aging and cellular mechanisms… (More)

Development of a model for the delta opioid receptor pharmacophore. 2. Conformationally restricted Phe3 replacements in the cyclic delta receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH…

• Henry I. Mosberg, John R. Omnaas, +5 authors F rank Porreca
• Journal of medicinal chemistry
• 1994

The in vitro pharmacological properties and conformational features of analogs of the delta opioid receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM-13) in which the Phe3 residue was… (More)

Lipophilicity of opioids determined by a novel micromethod.

• Fedor Medzihradsky, Paul J. Emmerson, Carol Mousigian
• Journal of pharmacological and toxicological…
• 1992

The lipophilicity of various mu-selective opioids was determined by measuring their distribution between n-octanol and Tris.HCl buffer, pH 7.4, by a procedure requiring submicromolar concentrations… (More)

Development of a model for the delta opioid receptor pharmacophore. 1. Conformationally restricted Tyr1 replacements in the cyclic delta receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH…

• Henry I. Mosberg, Andrei L. Lomize, +6 authors F rank Porreca
• Journal of medicinal chemistry
• 1994

A series of analogues of the conformationally restricted delta opioid receptor selective tetrapeptide Tyr-c[D-Cys-Phe-D-Pen]OH (JOM 13) was prepared in which the conformationally labile Tyr residue… (More)

Opioid receptor binding requirements for the delta-selective peptide deltorphin. I: Phe3 replacement with ring-substituted and heterocyclic amino acids.

• Deborah L. Heyl, M Dandabathula, Kara Kurtz, Carol Mousigian
• Journal of medicinal chemistry
• 1995

In order to assess steric, lipophilic, and electronic influences on opioid binding affinity, analogs of the delta receptor selective peptide deltorphin I (Tyr-D-Ala-Phe-Asp-Val-Val-GlyNH2) were… (More)

Tetrachlorodibenzo-p-dioxin alters rat hypothalamic endorphin and mu opioid receptors.

• Lorelle L. Bestervelt, Clifford Joseph Nolan, Yong Cai, P Maimansomsuk, Carol Mousigian, W. N. Piper
• Neurotoxicology and teratology
• 1991

The present study was undertaken to assess if hypothalamic beta-endorphin (beta E) and/or brain mu opioid receptors are associated with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) (50… (More)

Structural requirements for binding to the δ opioid receptor: Alkyl replacements at the third residue of deltorphin I

• Deborah L. Heyl, Hassiba Bouzit, Carol Mousigian
• Letters in Peptide Science
• 2004

The naturally occurring heptapeptide deltorphin I (Tyr-d-Ala-Phe-Asp-Val-Val-Gly-NH2) exhibits extremely high affinity and selectivity for the δ opioid receptor. In an ongoing investigation of the… (More)

The role of backbone conformation in deltorphin II binding: a QSAR study of new analogues modified in the 5-, 6-positions of the address domain.

• Stephen E Schullery, David W. Rodgers, +5 authors Deborah L. Heyl
• Bioorganic & medicinal chemistry
• 2001

The delta selectivity of the opioid heptapeptides deltorphin I and II has been attributed to the C-terminal 'address' domain, the hydrophobic Val(5)-Val(6) residues apparently playing a topographical… (More)

Binding to delta and mu opioid receptors by deltorphin I/II analogues modified at the Phe3 and Asp4/Glu4 side chains: a report of 32 new analogues and a QSAR study.

• Stephen E Schullery, T Mohammedshah, +5 authors Deborah L. Heyl
• Bioorganic & medicinal chemistry
• 1997

The synthesis and binding affinities of 32 X3Gly4 dual-substitution analogues of the natural opioid heptapeptides deltorphin I and II are reported. A multiple regression QSAR analysis was performed… (More)

Chronic ethanol consumption depresses hypothalamic-pituitary-adrenal function in aged rats.

• Clifford Joseph Nolan, Lorelle L. Bestervelt, Carol Mousigian, P Maimansomsuk, Yong Cai, W. N. Piper
• Life sciences
• 1991

In separate experiments, nine (n = 20) and fifteen (n = 12) month old rats were treated with either 6% ethanol or 12% sucrose (to balance caloric intake) in the drinking water to examine the effect… (More)

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