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Interstitial lung disease in systemic sclerosis: a simple staging system.

• Nicole S L Goh, Sujal R. Desai, +12 authors Athol U Wells
• American journal of respiratory and critical care…
• 2008

RATIONALE In interstitial lung disease complicating systemic sclerosis (SSc-ILD), the optimal prognostic use of baseline pulmonary function tests (PFTs) and high-resolution computed tomography (HRCT)… (More)

CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling.

• Alan G. Holmes, David J. Abraham, S. A. Mendes de Sá, Xu Shiwen, Carol Mary Black, Andrew Leask
• The Journal of biological chemistry
• 2001

In normal adult fibroblasts, transforming growth factor-beta (TGFbeta) induces the expression of connective tissue growth factor (CTGF). CTGF independently promotes fibroblast proliferation and… (More)

Tumor necrosis factor alpha suppresses the induction of connective tissue growth factor by transforming growth factor-beta in normal and scleroderma fibroblasts.

• David J. Abraham, Xu Shiwen, Carol Mary Black, S. A. Mendes de Sá, Yingqian Xu, Andrew Leask
• The Journal of biological chemistry
• 2000

Connective tissue growth factor (CTGF) is overexpressed in a variety of fibrotic disorders, presumably secondary to the activation and production of transforming growth factor-beta (TGF-beta), a key… (More)

Histopathologic subsets of fibrosing alveolitis in patients with systemic sclerosis and their relationship to outcome.

• Demosthenes E Bouros, Athol U Wells, +7 authors Roland M du Bois
• American journal of respiratory and critical care…
• 2002

Fibrosing alveolitis associated with systemic sclerosis (FASSc) has a better prognosis than idiopathic pulmonary fibrosis. In view of recent reports that idiopathic nonspecific interstitial pneumonia… (More)

Role of N-terminal brain natriuretic peptide (N-TproBNP) in scleroderma-associated pulmonary arterial hypertension.

• Mark H Williams, Clive E. Handler, +7 authors John Gerry Coghlan
• European heart journal
• 2006

AIMS The aims of this study were to evaluate the diagnostic value and to explore the prognostic value of N-terminal brain natriuretic peptide (N-TproBNP) in patients with systemic sclerosis (SSc)… (More)

A multicenter, prospective, randomized, double-blind, placebo-controlled trial of corticosteroids and intravenous cyclophosphamide followed by oral azathioprine for the treatment of pulmonary…

• Rachel K. Hoyles, Ross W Ellis, +15 authors Roland M du Bois
• Arthritis and rheumatism
• 2006

OBJECTIVE The lack of randomized controlled trials (RCTs) in pulmonary fibrosis in systemic sclerosis (SSc) has hampered an evidence-based approach to treatment. This RCT was undertaken to… (More)

Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts.

• Andrew Leask, Alan G. Holmes, Carol Mary Black, David J. Abraham
• The Journal of biological chemistry
• 2003

In skin, the profibrotic protein connective tissue growth factor (CTGF) is not normally expressed. However, when skin cells are exposed to transforming growth factor-beta (TGF-beta), CTGF is induced… (More)

Ligand-dependent genetic recombination in fibroblasts : a potentially powerful technique for investigating gene function in fibrosis.

• Bing Zheng, Zhaoping Zhang, Carol Mary Black, Benoit de Crombrugghe, Christopher P. Denton
• The American journal of pathology
• 2002

Strategies for conditional induction of transgene expression in mice are likely to be valuable for testing the role of candidate genes in disease pathogenesis. We have developed a system for… (More)

Comparison of Doppler echocardiography and right heart catheterization to assess pulmonary hypertension in systemic sclerosis.

• Christopher P. Denton, J B Cailes, Gerrard D Phillips, Athol U Wells, Carol Mary Black, Roland M. du Bois
• British journal of rheumatology
• 1997

Pulmonary hypertension (PHT) is an important complication of systemic sclerosis (SSc). Echocardiography can be used to detect PHT and, with Doppler echocardiography, the pulmonary arterial systolic… (More)

Scleroderma renal crisis: patient characteristics and long-term outcomes.

• Henry Penn, Alexander J. Howie, +5 authors Christopher P. Denton
• QJM : monthly journal of the Association of…
• 2007

BACKGROUND Scleroderma renal crisis (SRC) is an important complication of systemic sclerosis, causing acute renal failure, and usually hypertension. AIMS To review the clinical and pathological… (More)

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