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Systemic Inflammation Induces Acute Behavioral and Cognitive Changes and Accelerates Neurodegenerative Disease

• Colm Cunningham, Suzanne L. Campion, +5 authors V Hugh Perry
• Biological Psychiatry
• 2009

BACKGROUND Chronic neurodegeneration results in microglial activation, but the contribution of inflammation to the progress of neurodegeneration remains unclear. We have shown that microglia express… (More)

Cyclooxygenase-1-dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction.

• Éadaoin W Griffin, Donal Thomas Skelly, Carol L. Murray, Colm Cunningham
• The Journal of neuroscience : the official…
• 2013

Systemic inflammatory events often precipitate acute cognitive dysfunction in elderly and demented populations. Delirium is a highly prevalent neuropsychiatric syndrome that is characterized by acute… (More)

Microglia in the degenerating brain are capable of phagocytosis of beads and of apoptotic cells, but do not efficiently remove PrPSc, even upon LPS stimulation

• Martina Mary Hughes, Robert H. Field, V Hugh Perry, Carol L. Murray, Colm Cunningham
• Glia
• 2010

Despite the phagocytic machinery available to microglia the aberrant amyloid proteins produced during Alzheimer's and prion disease, amyloid-β and PrP(Sc), are inefficiently cleared. We have shown… (More)

Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL-1β and IL-6

• Carol L. Murray, Donal Thomas Skelly, Colm Cunningham
• Journal of Neuroinflammation
• 2011

Chronic neurodegeneration comprises an inflammatory response but its contribution to the progression of disease remains unclear. We have previously shown that microglial cells are primed by chronic… (More)

Endogenous IL-1 in Cognitive Function and Anxiety: A Study in IL-1RI−/− Mice

• Carol L. Murray, Pauline Obiang, David Bannerman, Colm Cunningham
• PloS one
• 2013

Interleukin-1 (IL-1) is a key pro-inflammatory cytokine, produced predominantly by peripheral immune cells but also by glia and some neuronal populations within the brain. Its signalling is mediated… (More)

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