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Integral-based parameter identification for long-term dynamic verification of a glucose-insulin system model

• Christopher E. Hann, J. Geoffrey Chase, Jessica T Lin, Thomas Lotz, Carmen V. Doran, Geoffrey M. Shaw
• Computer Methods and Programs in Biomedicine
• 2005

Hyperglycaemia in critically ill patients increases the risk of further complications and mortality. This paper introduces a model capable of capturing the essential glucose and insulin kinetics in… (More)

Derivative weighted active insulin control algorithms and intensive care unit trials

• Carmen V. Doran, J. Geoffrey Chase, Geoffrey M. Shaw, Katherine T. Moorhead, Nicolas H. Hudson
• 2005

Critically ill-patients often experience stress-induced hyperglycemia. This research demonstrates the effectiveness of a simple automated insulin infusion for controlling the rise and duration of… (More)

Targeted glycemic reduction in critical care using closed-loop control.

• J. Geoffrey Chase, Geoffrey M. Shaw, +5 authors Bob Broughton
• Diabetes technology & therapeutics
• 2005

BACKGROUND Critically ill patients are often hyperglycemic and extremely diverse in their dynamics. Consequently, fixed protocols and sliding scales can result in error and poor control. Tight… (More)

Automated insulin infusion trials in the intensive care unit.

• Carmen V. Doran, J. Geoffrey Chase, Geoffrey M. Shaw, Katherine T. Moorhead, Nicolas H. Hudson
• Diabetes technology & therapeutics
• 2004

The objective is to demonstrate the effectiveness of a simple automated insulin infusion for controlling the rise and duration of blood glucose excursion following a glucose challenge in critically… (More)

Adaptive bolus-based targeted glucose regulation of hyperglycaemia in critical care.

• J. Geoffrey Chase, Geoffrey M. Shaw, +7 authors Bob Broughton
• Medical engineering & physics
• 2005

Tight regulation of blood glucose can significantly reduce mortality in critical illness. Critically ill patients are extremely diverse in the dynamics of their hyperglycaemia. Hence, responses can… (More)

Derivative weighted active insulin control modelling and clinical trials for ICU patients.

• Carmen V. Doran, Nicolas H. Hudson, Katherine T. Moorhead, J. Geoffrey Chase, Geoffrey M. Shaw, Chris E. Hann
• Medical engineering & physics
• 2004

Close control of blood glucose levels significantly reduces vascular complications in Type 1 and Type 2 diabetic individuals. Heavy derivative controllers using the data density available from… (More)

Impact of insulin-stimulated glucose removal saturation on dynamic modelling and control of hyperglycaemia

• J. Geoffrey Chase, Geoffrey M. Shaw, +6 authors Thomas Lotz
• IJISTA
• 2005

Reported insulin-stimulated glucose removal saturation levels vary widely between individuals and trade off with insulin sensitivity in model-based control methods. A non-linear model and adaptive… (More)

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