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Hyperglycaemia in critically ill patients increases the risk of further complications and mortality. This paper introduces a model capable of capturing the essential glucose and insulin kinetics in patients from retrospective data gathered in an intensive care unit (ICU). The model uses two time-varying patient specific parameters for glucose effectiveness(More)
Reported insulin-stimulated glucose removal saturation levels vary widely between individuals and trade off with insulin sensitivity in model-based control methods. A non-linear model and adaptive insulin infusion protocol enabled high-precision blood glucose control in critically ill patients using a constant insulin-stimulated glucose removal saturation(More)
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