Carmen Smarandache

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Synchronization of distributed neural circuits is required for many behavioral tasks, but the mechanisms that coordinate these circuits are largely unknown. The modular local circuits that control crayfish swimmerets are distributed in four segments of the CNS, but when the swimmeret system is active their outputs are synchronized with a stable(More)
Half a century ago, two independent papers that described unexpected results of experiments on locomotion in insects and crayfish appeared almost simultaneously. Together these papers demonstrated that an animal's central nervous system (CNS) was organized to produce behaviorally important motor output without the need for constant sensory feedback. These(More)
One of the fundamental challenges in neuroscience is to understand how the intrinsic properties of neurons and the properties of neural networks combine to produce behavior. Networks that produce rhythmic motor behaviors, such as locomotion, provide important model systems to address this problem. A particularly good model for this purpose is the neural(More)
Half-center oscillators are widely used as models for central pattern generators. They consist of two cells (or groups of cells) connected by relatively strong reciprocal inhibition. Typically, the individual cells are phaselocked in an anti-phase state, where one cell is active while the other is suppressed, and vice versa. In central pattern generators,(More)
INTRODUCTION The diagnosis of esophago gastric junction adenocarcinoma often occurs when the neoplastic process is surprised in advanced stages and blocks the esophageal-gastric junction causing dysphagia, stages in which curative therapy is more likely impossible to be accomplished. In these cases, the treatment goal is mainly to provide feeding capacity(More)
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