Carmen Scheibenbogen

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Chemokine Receptor CCR6 Expression Level and Liver Metastases in Colorectal Cancer

Pirus Ghadjar, Sarah E Coupland, +8 authors Ulrich Keilholz
Journal of clinical oncology : official journal…
2006

PURPOSE The liver is the primary organ of metastasis in colorectal cancer (CRC). Chemokine receptor CCR6 is expressed on a subset of T cells and is associated with their migration into the liver.… (More)

Human CD1c+ dendritic cells secrete high levels of IL-12 and potently prime cytotoxic T-cell responses.

Giulia Nizzoli, Jana Krietsch, +16 authors Jens Geginat
Blood
2013

Dendritic cells (DC) have the unique capacities to induce primary T-cell responses. In mice, CD8α(+)DC are specialized to cross-prime CD8(+) T cells and produce interleukin-12 (IL-12) that promotes… (More)

CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia.

Carmen Scheibenbogen, Anne Letsch, +5 authors Ulrich Keilholz
Blood
2002

Wilms tumor gene product WT1 and proteinase 3 are overexpressed antigens in acute myeloid leukemia (AML), against which cytotoxic T lymphocytes can be elicited in vitro and in murine models. We… (More)

Immunologic monitoring of cancer vaccine therapy: results of a workshop sponsored by the Society for Biological Therapy.

Ulrich Keilholz, Jeffrey S. Weber, +13 authors Michael B. Atkins
Journal of immunotherapy
2002

The Society for Biological Therapy held a Workshop last fall devoted to immune monitoring for cancer immunotherapy trials. Participants included members of the academic and pharmaceutical communities… (More)

Quantitative DNA methylation analysis of FOXP3 as a new method for counting regulatory T cells in peripheral blood and solid tissue.

Georg Wieczorek, Anne Marie Asemissen, +17 authors Sven Olek
Cancer research
2009

Regulatory T-cells (Treg) have been the focus of immunologic research due to their role in establishing tolerance for harmless antigens versus allowing immune responses against foes. Increased Treg… (More)

Bone marrow contains melanoma-reactive CD8+ effector T cells and, compared with peripheral blood, enriched numbers of melanoma-reactive CD8+ memory T cells.

Anne Letsch, Ulrich Keilholz, Geraldine Assfalg, Volker Mailaender, Eckhard Thiel, Carmen Scheibenbogen
Cancer research
2003

Circulating melanoma-specific T cells can be frequently detected in patients with melanoma. Effective T-cell immunity and tumor surveillance, however, requires the presence of specific T cells in… (More)

A clinical and immunologic phase 2 trial of Wilms tumor gene product 1 (WT1) peptide vaccination in patients with AML and MDS.

Ulrich Keilholz, Anne Letsch, +7 authors Carmen Scheibenbogen
Blood
2009

This study investigated the immunogenicity of Wilms tumor gene product 1 (WT1)-peptide vaccination in WT1-expressing acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients without… (More)

Circulating Tumor-reactive CD8(+) T cells in melanoma patients contain a CD45RA(+)CCR7(-) effector subset exerting ex vivo tumor-specific cytolytic activity.

Danila Valmori, Carmen Scheibenbogen, +13 authors Ulrich Keilholz
Cancer research
2002

To defend the host from malignancies, the immune system can spontaneously raise CD8(+) T-cell responses against tumor antigens. Investigating the functional state of tumor-reactive cytolytic T cells… (More)

Natural T-cell response against MHC class I epitopes of epithelial cell adhesion molecule, her-2/neu, and carcinoembryonic antigen in patients with colorectal cancer.

Dirk Nagorsen, Ulrich Keilholz, +7 authors Carmen Scheibenbogen
Cancer research
2000

The antigens epithelial cell adhesion molecule (Ep-CAM), her-2/neu, and carcinoembryonic antigen (CEA) are potential T-cell targets in antigen-specific vaccination-based cancer therapy. We performed… (More)

Differences in T-cell immunity toward tumor-associated antigens in colorectal cancer and breast cancer patients.

Dirk Nagorsen, Carmen Scheibenbogen, +5 authors Ulrich Keilholz
International journal of cancer
2003

There is increasing evidence that tumors elicit specific T-cell responses in a substantial proportion of patients. Recently, we have shown that in patients with colorectal cancer specific T cells… (More)

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