Carmen Pedraz

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BACKGROUND Respiratory syncytial virus (RSV) is a major cause of hospitalization in preterm infants and infants with chronic lung disease (CLD). Palivizumab, a humanized monoclonal antibody, was approved in Europe in 1999 as prophylaxis against severe RSV-related respiratory illness. No multiple season data have been published on palivizumab effectiveness(More)
OBJECTIVE The purpose of the study was to develop and validate a clinical instrument predicting the risk of respiratory syncytial virus (RSV)-associated hospitalization (RSV-H) in premature infants born at 33 through 35 completed weeks of gestation (33-35GA). DESIGN An RSV risk scoring tool (RSV-RS) was developed by entering risk factors for RSV-H,(More)
Aims: To examine the morphometric changes produced on lung of neonatal rats treated with prenatal administration of betamethasone or dexamethasone, and test the hypothesis if glucocorticoids would produce any difference when pups are exposed to hypoxia and its recovery with oxygen or air ambient.Material and Methods: Dexamethasone, Bethametasone or(More)
Vascular endothelial growth factor (VEGF) is an endothelial cell growth factor expressed in normal lung tissue. The aim of the study was to investigate the expression of VEGF and its repercussions as regards alveolarization in the developing rat lung. We studied pulmonary VEGF expression at 0 and 14 days of life in Wistar rats. Rat pups were exposed to(More)
ABSTRACT: Many newborn mammals decrease metabolism and body temperature (Tb) during acute hypoxia. We asked what effects warming of the hypoxic newborn would have on these variables. In unanesthetized newborn cats and dogs, we measured the breathing pattern, CO2 production, Tb, and ambient temperature during normoxia at an ambient temperature of 28°C, 30(More)
Development of human C. system was studied by quantification of total serum hemolytical activity (CH50) and individual levels of C3, C4 and C5 in full term newborns. Comparison of results in newborn infants and their mothers sera is made. The ratios of neonatal-maternal sera concentrations were CH50, 0.29; C3, 0.61; C4, 0.51, and C5, 0.63. Serum(More)
Chemotactic activity in 58 full term newborn and in infants during the first year of life was studied. Samples were taken from cord blood and blood drawn at three and 15 days after birth and at one, three, six and 12 month of age. Chemotactic activity was assessed by Boyden's technique. It was found that samples obtained before the first month of life had a(More)
Serum opsonic capacity for "Staph. aureus" was studied in 58 full term infants at birth and through their 1st year of life. The comparison between serum opsonic activity from the infants and their mothers disclosed that infants had a significant decrease of the opsonic activity during the first three months of life. The study of serum levels of C3, C4, IgG(More)
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