Carmen Maria Helena Colitz

Learn More
Exposure to ultraviolet radiation (UVR) and reactive oxygen species (ROS) can damage the human lens and contribute to cataract formation. Recent evidence suggests that apoptosis in lens epithelial cells (LEC) is an initiating event in noncongenital cataract formation in humans and animals. The present study examines the cellular and molecular mechanisms by(More)
Telomerase is a ribonucleoprotein responsible for maintaining telomere length, preventing chromosomal degradation and recombination, and repairing DNA strand breaks. These activities are believed to be important in preventing cell senescence. Telomerase activity is normally found in germinal, neoplastic and stem cells, but not any ocular tissue studied to(More)
OBJECTIVE To determine risk factors for lens luxation and cataracts in captive pinnipeds in the United States and the Bahamas. DESIGN Cross-sectional study. ANIMALS 111 pinnipeds (99 California sea lions [Zalophus californianus], 10 harbor seals [Phoca vitulina], and 2 walruses [Odobenus rosmarus]) from 9 facilities. PROCEDURES Eyes of each pinniped(More)
OBJECTIVE A retrospective review of globes from 70 pinnipeds submitted to the Comparative Ocular Pathology Laboratory of Wisconsin (COPLOW) describing the type and frequency of ocular disease. ANIMALS STUDIED The study included 50 California sea lions, four animals listed only as 'sea lion', nine Northern elephant seals, five harbor seals, 1 Northern fur(More)
Immunohistochemical techniques were used to investigate the origin of a spindle cell tumor in the anterior uveal tract of dogs and the influence of ultraviolet radiation on the development of this tumor. Thirteen tumors were identified from the 4,007 canine ocular samples examined at the Comparative Ocular Pathology Laboratory of Wisconsin between 1978 and(More)
OBJECTIVE To characterize a form of progressive keratitis that occurs commonly in otariids. MATERIALS AND METHODS One hundred and thirteen captive otariids were evaluated by ophthalmologic examination and digital photography. RESULTS Forty-six females and 67 males were in the reference population, average age of 14 years. California sea lions(More)
PURPOSE To determine whether the catalytic subunit of telomerase reverse transcriptase (TERT) is regionally distributed in canine lens epithelial cells (LEC), compare TERT and the RNA subunit of telomerase (TR) mRNA expression and TERT protein expression in normal and cataractous LEC, and to evaluate whether telomerase activity is present in the cytoplasm(More)
Posterior capsular opacification (PCO) is the most common postoperative complication of contemporary cataract surgery. Limited information is available regarding PCO formation and factors that influence PCO development in the dog. Two hundred sixty-five eyes (144 from diabetic dogs and 121 from dogs with breed-related cataracts) were prospectively evaluated(More)
OBJECTIVE To evaluate effect of adjunctive treatment with tetracycline analogues on time to complete corneal reepithelialization in dogs with nonhealing (ie, refractory) corneal ulcers. DESIGN Randomized controlled clinical trial. ANIMALS 89 dogs with refractory corneal ulcers. PROCEDURES Corneal ulcers were treated via debridement and grid(More)
OBJECTIVE To determine histologic and immunohistochemical characteristics of the multifocal adherent plaques that commonly develop on the internal surfaces of the anterior and posterior lens capsules in dogs with cataracts. SAMPLE POPULATION 31 anterior and 4 posterior capsular specimens collected during lens extraction surgery in dogs with cataracts. (More)