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TGF-beta3 is required for the adhesion and intercalation of medial edge epithelial cells during palate fusion.
Transforming growth factor-beta3 (TGF-beta3) plays a critical role during palate development, since mutations of the TGF-beta3 gene give rise to cleft palate in both humans and mice. StrikingExpand
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A new technique for feeding dogs with a congenital cleft palate for surgical research
In humans, cleft palate (CP) is one of the most common malformations. Although surgeons use palatoplasty to close CP defects in children, its consequences for subsequent facial growth have promptedExpand
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Inactivation of p16 by CpG hypermethylation in renal cell carcinoma.
OBJECTIVE Renal carcinoma develops as a consequence of the accumulation of several genetic aberrations. Alterations in the p16 gene have been described in many tumors. Methylation of its promoter inExpand
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Loss of heterozygosity and methylation of p16 in renal cell carcinoma
To investigate the possible role of genomic aberrations of chromosome 9p21 in the tumorigenesis of human renal cell carcinoma (RCC), 40 sporadic RCCs were studied using PCR analyses. The tumours wereExpand
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