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- Marnix H. Medema, Renzo Kottmann, +151 authors Frank Oliver Glöckner
- Nature chemical biology
- 2015
Living organisms produce a range of secondary metabolites with exotic chemical structures and diverse metabolic origins. Many of these secondary metabolites find use as natural products in medicine,… (More)
Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074
- Carlos Olano, Ignacio Bergillos García, +7 authors José A Salas
- Microbial biotechnology
- 2014
Streptomyces albus J1074 is a streptomycete strain widely used as a host for expression of secondary metabolite gene clusters. Bioinformatic analysis of the genome of this organism predicts the… (More)
- Carlos Olano, Cristina Hilario Gomez, +6 authors José A Salas
- Chemistry & biology
- 2009
The biosynthetic gene cluster for the dienoyltetramic acid streptolydigin was identified and characterized from the producer organism Streptomyces lydicus NRRL2433. Sequence analysis of an 80.8 kb… (More)
- Luis M Quirós, Ignacio Aguirrezabalaga, Carlos Olano, Carmen Méndez, José A Salas
- Molecular microbiology
- 1998
A 5.2 kb region from the oleandomycin gene cluster in Streptomyces antibioticus located between the oleandomycin polyketide synthase gene and sugar biosynthetic genes was cloned. Sequence analysis… (More)
- C. Sánchez, Igor A. Butovich, Alfredo F. Braña, J. 0. Taylor Rohr, Carmen Méndez, José A Salas
- Chemistry & biology
- 2002
Rebeccamycin, a halogenated natural product of the indolocarbazole family, is produced by Saccharothrix aerocolonigenes ATCC39243. Several rebeccamycin analogues, which target DNA topoisomerase I or… (More)
- Yu Rebets, Bohdan Ostash, +6 authors Victor Fedorenko
- FEMS microbiology letters
- 2003
The regulatory genes lanI and lndI have been cloned from the landomycin A (LaA) producer Streptomyces cyanogenus S136 and from the landomycin E (LaE) producer Streptomyces globisporus 1912,… (More)
- Susanne Zehner, Alexander Kotzsch, +4 authors Karl-Heinz van Pée
- Chemistry & biology
- 2005
The antibiotic compound pyrroindomycin B contains an indole ring chlorinated in the 5 position. The indole ring is probably derived from tryptophan, and thus primers derived from conserved regions of… (More)
- Nuria Sanz Menéndez, Mohammad Nur-E-Alam, Alfredo F. Braña, J. 0. Taylor Rohr, José A Salas, Carmen Méndez
- Chemistry & biology
- 2004
The biosynthetic gene cluster of the aureolic acid type antitumor drug chromomycin A3 from S. griseus subsp. griseus has been identified and characterized. It spans 43 kb and contains 36 genes… (More)
- Luz Elena Núñez, Stephen Eric Nybo, +9 authors Carmen Méndez
- Journal of medicinal chemistry
- 2012
Mithramycin is an antitumor compound produced by Streptomyces argillaceus that has been used for the treatment of several types of tumors and hypercalcaemia processes. However, its use in humans has… (More)
- Nuria Sanz Menéndez, Mohammad Nur-E-Alam, Alfredo F. Braña, J. 0. Taylor Rohr, José A Salas, Carmen Méndez
- Molecular microbiology
- 2004
Chromomycin A3 is a member of the aureolic acid group family of antitumour drugs. Three tailoring modification steps occur during its biosynthesis affecting the sugar moieties: two O-acetylations and… (More)