Carmen Cabrera

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BACKGROUND Overdistension and cyclic recruitment-derecruitment contribute to ventilator-induced lung injury. High tidal volumes are thought to increase mortality mainly by inducing overdistension. However, experimental evidence suggests that tidal volume (VT) may also influence cyclic recruitment-derecruitment. Our main goal was to determine whether high(More)
The employment of current treatments based on chemotherapy and immunotherapy leads to inmunosuppression. The presence of mutations or polymorphisms in genes related to immune system might involve an additional disadvantage. The aim of the present study was to analyze mannose-binding lectin (MBL-2 gene) mutations and their association with severe infections(More)
Bortezomib plus melphalan and prednisone (VMP) and lenalidomide plus low-dose dexamethasone (Rd) are 2 standards of care for elderly untreated multiple myeloma (MM) patients. We planned to use VMP and Rd for 18 cycles in a sequential or alternating scheme. Patients (233) with untreated MM, >65 years, were randomized to receive 9 cycles of VMP followed by 9(More)
The value of minimal residual disease (MRD) in multiple myeloma (MM) has been more frequently investigated in transplant-eligible patients than in elderly patients. Because an optimal balance between treatment efficacy and toxicity is of utmost importance in patients with elderly MM, sensitive MRD monitoring might be particularly valuable in this patient(More)
A comparative study was performed on the sensitivity of the determination of the available biochemical markers of bone formation — total and bone alkaline phosphatase (TAP and bAP, respectively), osteocalcin (BGP), procollagen I aminoterminal propeptide (PINP) and procollagen I carboxyterminal propeptide (PICP) — in the study of postmenopausal osteoporosis.(More)
BACKGROUND AND OBJECTIVE It has been reported that tobacco smoking slows the sterilisation of sputum culture in pulmonary tuberculosis, but the factors that could delay culture conversion in patients who smoke are not known. Our aim is to identify the factors influencing sputum culture conversion in smokers with pulmonary tuberculosis. METHODS Ninety-nine(More)
Following a modification of the area method described by Gelberg et al., left ventricular regional wall motion was studied in 30 normal subject. The left ventricular cineangiograms were filmed in the right anterior oblique projection at 48 frames/s after injection of 76% sodium-meglumine diatrizoate. The end-diastolic and end-systolic frames were each(More)
To the Editor: Investigators in the Study of the Effectiveness of Additional Reductions in Cholesterol and Homocysteine (SEARCH) Collaborative Group found one single-nucleotide polymorphism (SNP) in the SLCO1B1 gene that was significantly associated with the risk of development of statininduced myopathy (P = 4×10–9) (Aug. 21 issue).1 The study was performed(More)