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Characterization of disease-associated Orai1 mutants reveals the multistep gating mechanism for the CRAC channel. Characterizing cancer-associated Ca2+ channels Orai1 enables Ca2+ influx into cells… Expand
Background: STIM1 and Orai1 are key players in the store-operated Ca2+ entry. Results: The activation state of STIM1 is precisely controlled by heteromeric interaction between coiled-coil domains.… Expand
A new photochromic ligand enables high precision control over native TRPC channels.
Ca2+ release-activated Ca2+ (CRAC) channels constitute the major Ca2+ entry pathway into the cell. They are fully reconstituted via intermembrane coupling of the Ca2+-selective Orai channel and the… Expand
Calcium (Ca2+) is an essential second messenger required for diverse signaling processes in immune cells. Ca2+ release-activated Ca2+ (CRAC) channels represent one main Ca2+ entry pathway into the… Expand
Calcium signalling through store-operated calcium (SOC) entry is of crucial importance for T-cell activation and the adaptive immune response. This entry occurs via the prototypic Ca2+… Expand
Ca2+ release activated Ca2+ (CRAC) channels represent a primary pathway for Ca2+ to enter non-excitable cells. The two key players in this process are the stromal interaction molecule (STIM), a Ca2+… Expand
Herein we report the first photoswitchable inhibitor of Transient Receptor Potential Vanilloid 6 (TRPV6), a selective calcium channel involved in a number of diseases and in cancer progression. By… Expand