Carmela Gerarda Luana Raffaele

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Behçet's disease (BD) is universally recognized as a multisystemic inflammatory disease of unknown etiology with chronic course and unpredictable exacerbations: its clinical spectrum varies from pure vasculitic manifestations with thrombotic complications to protean inflammatory involvement of multiple organs and tissues. Treatment has been revolutionized(More)
The coexistence of celiac disease (CD) with autoimmune diseases is largely documented and there is increasing evidence that CD shares many predisposing susceptibility loci with juvenile idiopathic arthritis (JIA) [1]. The authors present a 13-year-old boy hospitalized for left tibiotarsal arthritis and metacarpophalangeal joint arthritis of all fingers of(More)
A retrospective multi-center data collection of clinical, laboratory, and treatment characteristics of 94 Caucasian children and adolescents with Raynaud’s phenomenon (RP) started at a mean age of 12.8 ± 5 years, with variable involvement of hands, feet, and face, was performed for a period of 3 years. Collected data included nailfold videocapillaroscopy(More)
Diagnosis of Behçet disease (BD), a chronic multisystemic vasculitis of unknown origin, can be made relying on the combination of recurrent oral ulcers plus 2 of the following signs: recurrent genital ulcerations, uveal or retinal disease, peculiar skin lesions (erythema nodosum and papulopustular/acneiform nodules), or a positive pathergy test.1 Cases of(More)
In selected cases, childhood’s recurrent fevers of unknown origin can be referred to systemic autoinflammatory diseases as mevalonate kinase deficiency (MKD), caused by mutations in the mevalonate kinase gene (MVK), previously named “hyper-IgD syndrome” due to its characteristic increase in serum IgD level. There is no clear evidence for studying MVK(More)
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