Carlota Dobaño

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Denise L. Doolan, Carlota Dobaño, John Kevin Baird
Clinical microbiology reviews
2009

Naturally acquired immunity to falciparum malaria protects millions of people routinely exposed to Plasmodium falciparum infection from severe disease and death. There is no clear concept about how… (More)

Identification of Plasmodium falciparum antigens by antigenic analysis of genomic and proteomic data.

Denise L. Doolan, Scott Southwood, +12 authors Alessandro Sette
Proceedings of the National Academy of Sciences…
2003

The recent explosion in genomic sequencing has made available a wealth of data that can now be analyzed to identify protein antigens, potential targets for vaccine development. Here we present, in… (More)

Intermittent preventive treatment for malaria control administered at the time of routine vaccinations in Mozambican infants: a randomized, placebo-controlled trial.

Eusébio V Macete, Pedro Carlos Paulino Aide, +9 authors Clara Menéndez
The Journal of infectious diseases
2006

BACKGROUND There is an urgent need to deploy and develop new control tools that will reduce the intolerable burden of malaria. Intermittent preventive treatment in infants (IPTi) has the potential to… (More)

Placental infection with Plasmodium vivax: a histopathological and molecular study.

Alfredo Mayor, Azucena Bardají, +11 authors Stephen Rogerson
The Journal of infectious diseases
2012

BACKGROUND Evidence of the presence of Plasmodium vivax in the placenta is scarce and inconclusive. This information is relevant to understanding whether P. vivax affects placental function and how… (More)

Pregnancy and malaria exposure are associated with changes in the B cell pool and in plasma eotaxin levels.

Pilar Requena, Joseph J. Campo, +20 authors Carlota Dobaño
Journal of immunology
2014

Pregnancy triggers immunological changes aimed to tolerate the fetus, but its impact on B lymphocytes is poorly understood. In addition, exposure to the Plasmodium parasite is associated with altered… (More)

The Role of Age and Exposure to Plasmodium falciparum in the Rate of Acquisition of Naturally Acquired Immunity: A Randomized Controlled Trial

Caterina Guinovart, Carlota Dobaño, +17 authors Pedro Luis Chas Alonso
PloS one
2012

BACKGROUND The rate of acquisition of naturally acquired immunity (NAI) against malaria predominantly depends on transmission intensity and age, although disentangling the effects of these is… (More)

An Autopsy Study of Maternal Mortality in Mozambique: The Contribution of Infectious Diseases

Clara Menéndez, Cleofé Romagosa, +11 authors Jaume Ordi
PLoS medicine
2008

BACKGROUND Maternal mortality is a major health problem concentrated in resource-poor regions. Accurate data on its causes using rigorous methods is lacking, but is essential to guide policy-makers… (More)

Comparison of commercial kits to measure cytokine responses to Plasmodium falciparum by multiplex microsphere suspension array technology

Tamara K Berthoud, Maria Nélia Manaca, +6 authors Carlota Dobaño
Malaria Journal
2011

Multiplex cytokine profiling systems are useful tools for investigating correlates of protective immunity. Several Luminex and flow cytometry methods are commercially available but there is limited… (More)

Relation between circulating CC16 concentrations, lung function, and development of chronic obstructive pulmonary disease across the lifespan: a prospective study.

S. Guerra, Marilyn J. Halonen, +25 authors Fernando D. Martinez
The Lancet. Respiratory medicine
2015

BACKGROUND Low concentrations of the anti-inflammatory protein CC16 (approved symbol SCGB1A1) in serum have been associated with accelerated decline in forced expiratory volume in 1 s (FEV1) in… (More)

Cytokine and Antibody Responses to Plasmodium falciparum in Naïve Individuals during a First Malaria Episode: Effect of Age and Malaria Exposure

Gemma Moncunill, Alfredo Mayor, +15 authors Carlota Dobaño
PloS one
2013

Age- and exposure-dependent immune responses during a malaria episode may be key to understanding the role of these factors in the acquisition of immunity to malaria. Plasma/serum samples collected… (More)

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