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Many high-performance computing applications solving partial differential equations (PDEs) can be attributed to the class of kernels using stencils on structured grids. Due to the disparity between floating point operation throughput and main memory bandwidth these codes typically achieve only a low fraction of peak performance. Unfortunately, stencil(More)
Limited knowledge exists about the impact of specific genetic abnormalities on the proliferation of neoplastic B cells from chronic lymphoproliferative disorders (B-CLPDs). Here we analyze the impact of cytogenetic abnormalities on the proliferation of neoplastic B cells in 432 B-CLPD patients, grouped according to diagnosis and site of sampling, versus(More)
We have constructed and operated the ICARUS T600 liquid argon (LAr) time projection chamber (TPC). The ICARUS T600 detector is the largest LAr TPC ever built, with a size of about 500 tons of fully imaging mass. The design and assembly of the detector relied on industrial support and represents the applications of concepts matured in laboratory tests to the(More)
Philadelphia-positive (Ph(+)) B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a genetically heterogeneous disease with a very poor prognosis. In this study, we analyzed the frequency of supernumerary Ph, trisomy 8, monosomy 7, and del(9p21) by FISH and its relationship with the characteristics of the disease, in 46 BCR/ABL(+) adult BCP-ALL(More)
BACKGROUND AND OBJECTIVE High plasma total homocysteine (tHcy), low dietary intake of folate and other B vitamins, and genetic polymorphisms related to the metabolism of homocysteine may interactively contribute to the risk of cerebral vascular disease (CVD). We explored interrelations between total homocysteine levels and mutations in genes for the two key(More)
Obstructive sleep apnoea (OSA) is associated with pharyngeal inflammation, but the coexistence of systemic inflammation is controversial. This study investigated whether local and systemic inflammatory biomarkers are related in patients with OSA. An uncontrolled extension to the study assessed the response to effective treatment.We recruited 89 patients(More)
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