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Cerebrolysin (Cere) is a compound with neurotrophic activity shown to be effective in Alzheimer's disease in earlier trials. The efficacy and safety of three dosages of Cere were investigated in this randomized, double-blind, placebo-controlled, study. Two hundred and seventy-nine patients were enrolled (69 Cere 10 ml; 70 Cere 30 ml; 71 Cere 60 ml and 69(More)
Reduced brain-derived neurotrophic factor (BDNF) signaling is considered as a pathogenic event in early Alzheimer's disease (AD), but the influence of apathy and apolipoprotein E ε4 allele (APOE4) on serum BDNF values was not previously investigated in AD. We evaluated serum BDNF levels in AD, amnestic mild cognitive impairment (MCI), and control subjects.(More)
According to current scientific knowledge, excess tumour necrosis factor-α (TNF-α) and low insulin-like growth factor-I (IGF-I) are pathogenic-risk factors that constitute therapeutic targets for Alzheimer's disease (AD). Changes in serum TNF-α, total and dissociable IGF-I levels were determined by ELISA in 207 AD patients completing a 24-wk, double-blind,(More)
BACKGROUND cerebrolysin is a neuropeptide preparation mimicking the effects of neurotrophic factors. This subgroup analysis assessed safety and efficacy of Cerebrolysin in patients with moderate to moderately severe Alzheimer's disease (AD) (ITT data set: N = 133; MMSE: 14-20) included in a dose-finding study (ITT data set: N = 51; MMSE: 14-25). Results of(More)
Currently a standard technique to compute the heuris-tic in heuristic planning is to expand a planning graph on the relaxed problem. This paper presents a new approach to expand the planning graph, such that heuris-tic estimations are more accurate when an optimization metric criteria is given. Additionally, a new kind of Hill-Climbing search that combines(More)
Game playing has always been a good testbed for AI research. In particular, real time strategy (RTS) games are characterized by being complex environments which offer multiple opportunities for AI researchers. In this work, we use AI planning and apply it to a RTS game. More specifically, we have defined a domain using PDDL2.1 that can be used by a computer(More)
It has been shown that right ventricle (RV) hypertrophy involves significant compensatory vascular growth and remodeling. The objective of the present study was to determine the functional implications of the vascular growth and remodeling through a full flow analysis of arterial tree down to first capillary segments. A computer reconstruction of RV(More)
According to current scientific knowledge, excess tumour necrosis factor-a (TNF-a) and low insulin-like growth factor-I (IGF-I) are pathogenic-risk factors that constitute therapeutic targets for Alzheimer's disease (AD). Changes in serum TNF-a, total and dissociable IGF-I levels were determined by ELISA in 207 AD patients completing a 24-wk, double-blind,(More)
Skin intrinsic fluorescence is associated with hemoglobin A 1c and hemoglobin glycation index but not mean blood glucose in children with type 1 diabetes. In the print version of the article listed above, on page 1817, the sentence " For the second k x /k m set (set c), k x and k m were 0.5 and 0, respectively, which is useful for populations with a wide(More)
BACKGROUND Low circulating brain derived neurotrophic factor may promote cognitive deterioration, but the effects of neurotrophic and combination drug therapies on serum brain derived neurotrophic factor were not previously investigated in Alzheimer's disease. METHODS We evaluated the effects of Cerebrolysin, donepezil, and the combined therapy on brain(More)