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Inguinal hernias may contain the small or large bowel. About 10% of inguinal hernias become incarcerated, causing strangulation, bowel obstruction or infarction. Malignant lesions in groin hernias are rare; most intrasaccular neoplasms are colonic, and the most common reported site is the sigmoid colon, usually in a left inguinal hernia. We report a case of(More)
G-protein coupled receptors are a diverse group that are the target of over 50% of marketed drugs. Activation of these receptors results in the exchange of bound GDP for GTP in the Gα subunit of the heterotrimeric G-protein. The Gα subunit dissociates from the β/γ subunits and both proceed to affect downstream signaling targets. The signal terminates by the(More)
Regulator of G protein signaling (RGS) proteins act to temporally modulate the activity of G protein subunits after G protein-coupled receptor activation. RGS proteins exert their effect by directly binding to the activated Galpha subunit of the G protein, catalyzing the accelerated hydrolysis of GTP and returning the G protein to its inactive,(More)
In this paper we describe ItLv (Interactive Timeline Viewer), a visualization tool currently used to depict the variants obtained in a textual collation. A textual collation is a process in which a base text is compared against several comparison texts to identify differences (variants) among them. The interactive options of ItLv provide different(More)
As part of the Cervantes Project digital library, we are developing an Electronic Variorum Edition (EVE) of Don Quixote de la Mancha. Multiple editors can create an EVE with our Multi Variant Editor for Documents (MVED), which allows collation of one base text against several comparison texts to identify, link and edit all existing variants among them. In(More)
The Cervantes Project is creating an Electronic Variorum Edition (EVE) of Cervantes' well-known <i>Don Quixote de la Mancha</i>, published beginning in 1605. In this paper, we report on visualizations of features of a text collection that help us validate our text transcriptions and understand the relationships among the different printings of an edition.
Oxidative stress has been implicated as a component of various pathologies including ischemia/reperfusion injury (IRI) and neurodegenerative diseases such as Parkinson's disease (PD) and schizophrenia. Similarly, regulator of G-protein signaling 4 (RGS4) has been implicated as an important player in each of these pathologies. RGS4, like other RGS proteins,(More)
The works of a significant author are accompanied by a variety of ar-tifacts ranging from the scholarly to the popular. In order to better support the needs of the scholarly community, digital libraries focused on the life and works of a particular author must be designed to assemble, integrate, and present the full scope of these artifacts. Drawing from(More)
In Nautical Archaeology, the study of components and objects creates a complex environment for scholars and researchers. Nautical archaeologists access, manipulate, study, and consult a variety of sources from different media, geographical origins, ages, and languages. Representing underwater excavations is a challenging endeavor due to the large amount of(More)