Carlos Monroy

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G-protein coupled receptors are a diverse group that are the target of over 50% of marketed drugs. Activation of these receptors results in the exchange of bound GDP for GTP in the Gα subunit of the heterotrimeric G-protein. The Gα subunit dissociates from the β/γ subunits and both proceed to affect downstream signaling targets. The signal terminates by the(More)
Regulator of G protein signaling (RGS) proteins act to temporally modulate the activity of G protein subunits after G protein-coupled receptor activation. RGS proteins exert their effect by directly binding to the activated Galpha subunit of the G protein, catalyzing the accelerated hydrolysis of GTP and returning the G protein to its inactive,(More)
Inguinal hernias may contain the small or large bowel. About 10% of inguinal hernias become incarcerated, causing strangulation, bowel obstruction or infarction. Malignant lesions in groin hernias are rare; most intrasaccular neoplasms are colonic, and the most common reported site is the sigmoid colon, usually in a left inguinal hernia. We report a case of(More)
Oxidative stress has been implicated as a component of various pathologies including ischemia/reperfusion injury (IRI) and neurodegenerative diseases such as Parkinson's disease (PD) and schizophrenia. Similarly, regulator of G-protein signaling 4 (RGS4) has been implicated as an important player in each of these pathologies. RGS4, like other RGS proteins,(More)
Access to materials in digital collections has been extensively studied within digital libraries. Exploring a collection requires customized indices and novel interfaces to allow users new exploration mechanisms. Materials or objects can then be found by way of full-text, faceted, or thematic indexes. There has been a marked interest not only in finding(More)
In this paper we describe ItLv (Interactive Timeline Viewer), a visualization tool currently used to depict the variants obtained in a textual collation. A textual collation is a process in which a base text is compared against several comparison texts to identify differences (variants) among them. The interactive options of ItLv provide different(More)
As part of the Cervantes Project digital library, we are developing an Electronic Variorum Edition (EVE) of Don Quixote de la Mancha. Multiple editors can create an EVE with our Multi Variant Editor for Documents (MVED), which allows collation of one base text against several comparison texts to identify, link and edit all existing variants among them. In(More)
The design of medical devices directly affects the way healthcare practitioners carry out their daily tasks. Users welcome design that takes into account the clinical environment, in which the device is operated and is compatible with their workflow. However, if the design fails to fit, the likelihood of errors increases, which will put patient safety at(More)
The Cervantes Project is creating an Electronic Variorum Edition (EVE) of Cervantes' well-known <i>Don Quixote de la Mancha</i>, published beginning in 1605. In this paper, we report on visualizations of features of a text collection that help us validate our text transcriptions and understand the relationships among the different printings of an edition.