Carlos Machahua

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BACKGROUND There is growing interest in the development of cell culture assays that enable the rigidity of the extracellular matrix to be increased. A promising approach is based on three-dimensional collagen type I matrices that are stiffened by cross-linking through non-enzymatic glycation with reducing sugars. METHODS The present study evaluated the(More)
Author details Department of Pneumology, Unit of Interstitial Lung Diseases, University Hospital of Bellvitge, Barcelona, Spain. Pneumology Research Group, IDIBELL, University of Barcelona, Barcelona, Spain. Unit of Biophysics and Bioengineering, University of Barcelona, Barcelona, Spain. Department of Preventive Medicine, University Hospital of Bellvitge,(More)
BACKGROUND The abnormal epithelial-mesenchymal restorative capacity in idiopathic pulmonary fibrosis (IPF) has been recently associated with an accelerated aging process as a key point for the altered wound healing. The advanced glycation end-products (AGEs) are the consequence of non-enzymatic reactions between lipid and protein with several oxidants in(More)
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