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  • Andrei V Bakin, Anne K. Tomlinson, Nandini Bhowmick, Harold L Moses, Carlos L. Arteaga
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2000 (First Publication: 24 November 2000)
  • We have studied the role of phosphatidylinositol 3-OH kinase (PI3K)-Akt signaling in transforming growth factor β (TGFβ)-mediated epithelial to mesenchymal transition (EMT). In NMuMG mammaryExpand
  • F. Michael Yakes, Wichai Chinratanalab, Christoph A. Ritter, Walter D. King, Steven A. Seelig, Carlos L. Arteaga
  • Biology, Medicine
  • Cancer research
  • 2002 (First Publication: 15 July 2002)
  • We have examined whether inhibition of phosphatidylinositol-3 kinase (PI3K) and its target, the serine/threonine kinase Akt, play a role in the antitumor effect of the HER2 antibody Herceptin.Expand
  • Stacy Moulder, F. Michael Yakes, Senthil K Muthuswamy, Roberto Bianco, Jean F. Simpson, Carlos L. Arteaga
  • Biology, Medicine
  • Cancer research
  • 2001 (First Publication: 15 December 2001)
  • Aberrrant signaling by the epidermal growth factor receptor [EGFR (HER1, erbB1)] and/or HER2/neu tyrosine kinases is present in a cohort of breast carcinomas. Because HER2 is constitutivelyExpand
  • Incheol Shin, F. Michael Yakes, +4 authors Carlos L. Arteaga
  • Medicine, Biology
  • Nature Medicine
  • 2002 (First Publication: 1 October 2002)
  • We have shown a novel mechanism of Akt-mediated regulation of the CDK inhibitor p27kip1. Blockade of HER2/neu in tumor cells inhibits Akt kinase activity and upregulates nuclear levels of the CDKExpand