Carlos Guillermo Hernandez

Learn More
Nitric oxide (NO) has been reported both to promote and to inhibit the activity of the transcription factor hypoxia-inducible factor-1 (HIF-1). In order to avoid the pitfalls associated with the use of NO donors, we have developed a human cell line (Tet-iNOS 293) that expresses the inducible NO synthase (iNOS) under the control of a tetracycline-inducible(More)
Plasma homocysteine (Hcy) is an independent risk factor for cardiovascular disease. Hcy is a nonprotein amino acid derivative that is generated from the methionine cycle, which provides the methyl group for essentially all biological methylation reactions. Although plasma Hcy levels are elevated in patients with cardiovascular disease, the mechanisms that(More)
BACKGROUND An elevated plasma homocysteine (Hcy) level has been prospectively associated with an increased risk of vascular and degenerative dementias. An Hcy elevation is prevalent in patients with Parkinson disease (PD) in part because levodopa metabolism produces Hcy. The clinical relevance of an elevated Hcy level in patients with PD is unknown. (More)
We analyzed the effects of chemically blocking type 1 muscarinic receptors (M1R) on either the left or right ovary on ovulation rate, number of ova shed and steroid hormones levels. M1R were unilaterally blocked in ovary with the M1R selective antagonist pirenzepine (PZP). PZP was delivered into the bursa ovarica of the left or right ovary of adult rats at(More)
Culture supernatants from the rice pathogenic fungus Pyricularia grisea were characterized by general proteolytic assays. Protease activity, as measured by azocasein hydrolysis, peaked over a pH range of 7.0 9.0 with an optimum at pH 8.0. This, together with the results from zymograms of gelatin-containing SDS-PAGE gels combine with specific protease(More)
Peroxisome proliferator-activated receptor (PPAR) γ coactivator-1β (PGC-1β) is a transcriptional coactivator that induces hypertriglyceridemia in response to dietary fats through activating hepatic lipogenesis and lipoprotein secretion. The expression of PGC-1β is regulated by free fatty acids. Here we show that PGC-1β regulates plasma triglyceride(More)
The Cyrtocarpa procera pulp was analysed for proximate composition and the effects of combining techniques such as addition of Potassium Sorbate (KS), modification of water activity (a ) and Heat treatment w (H) on the microbiological shelf life of C. procera pulp were evaluated during 100 days of storage at 25 C. o The experiment was laid out in a(More)
Li S, Arning E, Liu C, Vitvitsky V, Hernandez C, Banerjee R, Bottiglieri T, Lin JD. Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1 . Am J Physiol Endocrinol Metab 296: E543–E548, 2009. First published January 21, 2009; doi:10.1152/ajpendo.90719.2008.—Plasma homocysteine (Hcy) is an independent risk factor for(More)
  • 1