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Renal thrombotic microangiopathy caused by anti-VEGF-antibody treatment for metastatic renal-cell carcinoma.
A 70-year-old white man had undergone a left total nephrectomy in 1999 for a clear-cell renal carcinoma, with a residual glomerular fi ltration rate (GFR) of 41 mL/min per 1·73m without proteinuria.Expand
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Extracellular Calpains Increase Tubular Epithelial Cell Mobility
Calpains are intracellular Ca2+-dependent cysteine proteases that are released in the extracellular milieu by tubular epithelial cells following renal ischemia. Here we show that externalizedExpand
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