Carlos E. Alfonso

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OBJECTIVES This study sought to determine the incidence of new-onset atrial fibrillation (AF) associated with different methods of isolated aortic valve replacement (AVR)-transfemoral (TF), transapical (TA), and transaortic (TAo) catheter-based valve replacement and conventional surgical approaches. BACKGROUND The relative incidences of AF associated with(More)
OBJECTIVES This study sought to investigate the technical feasibility and safety of the transaortic (TAO) transcatheter aortic valve replacement (TAVR) approach in patients not eligible for transfemoral (TF) access by using a device commercially available in the United States. BACKGROUND A large proportion of candidates for TAVR have inadequate(More)
The incidence of hemolysis after ventricular assist device implantation is low and has been estimated at 3%.1 The Impella 2.5 (Abiomed; Danvers, MA) continuous-flow left ventricular assist device uses a microaxial pump that draws blood from the left ventricular cavity and expels it into the ascending aorta. The device is percutaneously inserted via the(More)
BACKGROUND Transradial access may be advantageous for patients with end-stage liver disease (ESLD) who need to undergo left heart catheterization (LHC). We aimed to assess the safety of transradial cardiac catheterization in patients listed for orthotopic liver transplantation. METHODS This is a retrospective analysis of consecutive adult patients with(More)
BACKGROUND Although human mesenchymal stem cells (hMSCs) have been tested in ischemic cardiomyopathy, few studies exist in chronic nonischemic dilated cardiomyopathy (NIDCM). OBJECTIVES The authors conducted a randomized comparison of safety and efficacy of autologous (auto) versus allogeneic (allo) bone marrow-derived hMSCs in NIDCM. METHODS(More)
OBJECTIVE The aim of the study was to assess the utilization of catheter-directed thrombolysis (CDT) and its comparative effectiveness against systemic thrombolysis in acute pulmonary embolism (PE). BACKGROUND Contemporary real world data regarding utilization and outcomes comparing systemic thrombolysis with CDT for PE is sparse. METHODS We queried the(More)
To determine whether pulmonary arterial hypertension (PAH) and pulmonary venous hypertension (PVH) can be differentiated noninvasively, we reviewed data on 44 patients with pulmonary artery systolic pressure greater than or equal to 40 mm Hg by echocardiography and cardiac catheterization performed within 7 days of each other. Based on left ventricular(More)
OBJECTIVE Evaluate the use of mechanical circulatory support (MCS) devices in high-risk patients undergoing transcatheter aortic valve replacement (TAVR). BACKGROUND The use of MCS devices in elderly patients with multiple comorbidities undergoing TAVR is underexplored. METHODS All patients undergoing TAVR at a single tertiary academic center who(More)
BACKGROUND With the expansion in the use of transcatheter valve therapies for aortic stenosis, the incidence of hemodynamically significant paravalvular regurgitation (PVR) has become a clinical challenge. METHODS The study population consisted of those patients with either acute significant PVR immediately post-Edwards SAPIEN (ES) aortic valve(More)