Carlos Barata

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In earlier single-species toxicity tests we showed the negative effects on the calanoid copepod Acartia tonsa upon exposure to cypermethrin, a pesticide used in treatment for sea lice in salmon farming. In the present study we assessed effects at a higher level of biological organization and under a more realistic exposure scenario using mesocosms. The(More)
Retinoic acid (RA) regulates many developmental processes through its binding to two types of nuclear receptors, the retinoic acid receptor (RAR), and the retinoid-X receptor (RXR), which preferentially binds to the 9-cis isomer. Here we analyzed the RAR/RXR regulatory system during the first 5 days of development of zebrafish. Analysis of the relative(More)
BACKGROUND The analysis of obesogenic effects in invertebrates is limited by our poor knowledge of the regulatory pathways of lipid metabolism. Recent data from the crustacean Daphnia magna points to three signaling hormonal pathways related to the molting and reproductive cycles [retinoic X receptor (RXR), juvenile hormone (JH), and ecdysone] as putative(More)
Climate change is a major concern for the scientific community, demanding novel information about the effects of environmental stressors on living organisms. Metabolic profiling is required for achieving the most extensive possible range of compounds and their concentration changes on stressed conditions. Individuals of the crustacean species Daphnia magna(More)
Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressants. As endocrine disruptive contaminants in the environment, SSRIs affect reproduction in aquatic organisms. In the water flea Daphnia magna, SSRIs increase offspring production in a food ration-dependent manner. At limiting food conditions, females exposed to SSRIs produce more(More)
The genome revolution has brought about a complete change on our view of biological systems. The quantitative determination of changes in all the major molecular components of the living cells, the "omics" approach, opened whole new fields for all health sciences, including toxicology. Endocrine disruption, i.e., the capacity of anthropogenic pollutants to(More)
The transcriptional response of adult zebra mussels (Dreissena polymorpha) to heavy metals (mercury, copper, and cadmium) was analyzed by quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) to study the coordinated regulation of different metal-, oxidative stress- and xenobiotic defence-related genes in gills and digestive gland. Regulatory network(More)
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A non-neglectable amount of information shared in social networks has quotes to literary works that, most of the times, is not linked to the original work or author. Also, there are erroneous quotes that do not fully match the original work, for example by including synonyms and slang words. Moreover, users sometimes associate their quotes to the wrong(More)
  • Miguel Gonçalo, Semedo Alves, Dissertaç˜ao, Dissertação Orientada, Pelo Prof Doutor, Fernando Manuel +13 others
  • 2008
2014 Acknowledgments First of all I want to thank my parents for all the support and encouragement that was fundamental for me to achieve my goals. Without them I would not got this far, not only because of all the investment they made in my education, but also because of all the love and firm hand that kept me in the right path. I like to thank my sister(More)
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