Carlos A. Villamizar

Learn More
Abnormalities in the cerebrovascular system play a central role in many neurologic diseases. The on-going expansion of rodent models of human cerebrovascular diseases and the need to use these models to understand disease progression and treatment has amplified the need for reproducible non-invasive imaging methods for high-resolution visualization of the(More)
RATIONALE Thoracic aortic aneurysms leading to acute aortic dissections (TAAD) can be inherited in families in an autosomal dominant manner. As part of the spectrum of clinical heterogeneity of familial TAAD, we recently described families with multiple members that had TAAD and intracranial aneurysms or TAAD and intracranial and abdominal aortic aneurysms(More)
Mutations in ACTA2, encoding the smooth muscle cell (SMC)-specific isoform of a-actin (a-SMA), cause thoracic aortic aneurysms and dissections and occlusive vascular diseases, including early onset coronary artery disease and stroke. We have shown that occlusive arterial lesions in patients with heterozygous ACTA2 missense mutations show increased numbers(More)
T horacic aortic aneurysms leading to acute aortic dissec-tions are a common cause of premature deaths in the United States. 1 Hypertension is the most common risk factor for thoracic aortic disease; >75% of patients with thoracic aor-tic aneurysms or acute aortic dissections have hypertension. 2 Despite the common association of hypertension and thoracic(More)
  • 1