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Modified Tat peptide with cationic lipids enhances gene transfection efficiency via temperature-dependent and caveolae-mediated endocytosis.

• Seiichi Yamano, Jisen Dai, Carlo Yuvienco, Sachin D Khapli, Amr M. Moursi, Jin Kim Montclare
• Journal of controlled release : official journal…
• 2011

The HIV-1 Tat peptide has been successfully used for intracellular gene delivery. Likewise, various lipid-based methods have shown increased endocytosis and can influence endosomal escape. This study… (More)

Long-term efficient gene delivery using polyethylenimine with modified Tat peptide.

• Seiichi Yamano, Jisen Dai, +8 authors Jin Kim Montclare
• Biomaterials
• 2014

Polyethylenimine (PEI), a cationic polymer, has been widely studied and shown great promise as an efficient gene delivery vehicle. Likewise, the HIV-1 Tat peptide, a cell-permeable peptide, has been… (More)

Engineered Protein Polymer-Gold Nanoparticle Hybrid Materials for Small Molecule Delivery

• Meixing Dai, JA Frezzo, +7 authors J K Montclare
• Journal of nanomedicine & nanotechnology
• 2016

We have fabricated protein polymer-gold nanoparticle (P-GNP) nanocomposites that exhibit enhanced binding and delivery properties of the small hydrophobic molecule drug, curcumin, to the model breast… (More)

Artificial protein block copolymers blocks comprising two distinct self-assembling domains.

• Jennifer S Haghpanah, Carlo Yuvienco, +7 authors Jin Kim Montclare
• Chembiochem : a European journal of chemical…
• 2009

Synthetic block copolymers comprising two or more compositionally distinct chains have attracted significant attention due to their ability to self-assemble into ordered microstructures. Although… (More)

Protein based therapeutic delivery agents: Contemporary developments and challenges.

• Liming Yin, Carlo Yuvienco, Jin Kim Montclare
• Biomaterials
• 2017

As unique biopolymers, proteins can be employed for therapeutic delivery. They bear important features such as bioavailability, biocompatibility, and biodegradability with low toxicity serving as a… (More)

Supramolecular assembly and small molecule recognition by genetically engineered protein block polymers composed of two SADs.

• Jennifer S Haghpanah, Carlo Yuvienco, Eric W Roth, Alice F. Liang, Raymond S Tu, Jin Kim Montclare
• Molecular bioSystems
• 2010

Genetically engineered protein block polymers are an important class of biomaterials that have gained significant attention in recent years due to their potential applications in biotechnology,… (More)

ElectroMechanical Membrane-Enabled Transfer ( EMMET ) System ME 5643 – Mechatronics Integrated Term Project , Fall 2009 Co-inventors

• Alberto Giacomello, Keeshan Williams, Carlo Yuvienco

Efficient siRNA delivery and gene silencing using a lipopolypeptide hybrid vector mediated by a caveolae-mediated and temperature-dependent endocytic pathway

• Hironori Kasai, Kenji Inoue, Kentaro Imamura, Carlo Yuvienco, Jin Kim Montclare, Seiichi Yamano
• Journal of nanobiotechnology
• 2019

BACKGROUND We developed a non-viral vector, a combination of HIV-1 Tat peptide modified with histidine and cysteine (mTat) and polyethylenimine, jetPEI (PEI), displaying the high efficiency of… (More)

Engineered Coiled-Coil Protein for Delivery of Inverse Agonist for Osteoarthritis.

• Liming Yin, Albert S Agustinus, +4 authors Jin Kim Montclare
• Biomacromolecules
• 2018

Osteoarthritis (OA) results from degenerative and abnormal function of joints, with localized biochemistry playing a critical role in its onset and progression. As high levels of all- trans retinoic… (More)

Improved stability and half-life of fluorinated phosphotriesterase using Rosetta.

• Ching-Yao Yang, P. Douglas Renfrew, +4 authors Jin Kim Montclare
• Chembiochem : a European journal of chemical…
• 2014

Recently we demonstrated that incorporating p-fluorophenylalanine (pFF) into phosphotriesterase dramatically improved folding, thereby leading to enhanced stability and function at elevated… (More)

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