Carlo Vincitorio

Learn More
OBJECTIVES To evaluate disease progression and determine validity of clinical tools for therapeutic trials. DESIGN Prospective cohort study (36 months). SETTING Referral center. PATIENTS One hundred sixty-two patients with autosomal dominant cerebellar ataxia and 64 with hereditary spastic paraplegia. MAIN OUTCOME MEASURES The quantitative Composite(More)
M itochondrial disorders are clinical phenotypes associated with abnormalities of the terminal component of mitochondrial energy metabolism—that is, oxida-tive phosphorylation. Oxidative phosphorylation is carried out in the inner mitochondrial membrane by the four enzyme complexes (I–IV), of the respiratory chain plus the adenosine triphosphate (ATP)(More)
  • 1