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BACKGROUND The ECG pattern of right bundle branch block and ST-segment elevation in leads V(1) to V(3) (Brugada syndrome) is associated with high risk of sudden death in patients with a normal heart. Current management and prognosis are based on a single study suggesting a high mortality risk within 3 years for symptomatic and asymptomatic patients alike.(More)
BACKGROUND In patients with syncope and bundle branch block (BBB), syncope is suspected to be attributable to a paroxysmal atrioventricular (AV) block, but little is known of its mechanism when electrophysiological study is negative. METHODS AND RESULTS We applied an implantable loop recorder in 52 patients with BBB and negative conventional workup.(More)
AIMS The guidelines of the European Society of Cardiology (ESC) define the current standard for the management of syncope, but are still incompletely applied in the clinical setting. METHODS AND RESULTS Prospective systematic evaluation, on strict adherence to the guidelines, of consecutive patients referred for syncope to the emergency departments of 11(More)
BACKGROUND Because of its episodic behavior, the correlation of spontaneous syncope with an abnormal finding can be considered a reference standard. METHODS AND RESULTS We inserted an implantable loop recorder in 111 patients with syncope, absence of significant structural heart disease, and a normal ECG; tilt-testing was negative in 82 (isolated syncope)(More)
OBJECTIVE To develop, in patients referred for syncope to an emergency department (ED), a diagnostic score to identify those patients likely to have a cardiac cause. DESIGN Prospective cohort study. SETTING ED of 14 general hospitals. PATIENTS 516 consecutive patients with unexplained syncope. INTERVENTIONS Subjects underwent a diagnostic evaluation(More)
AIMS Left ventricular (LV) and biventricular (BiV) pacing are potentially superior to right ventricular (RV) apical pacing in patients undergoing atrioventricular (AV) junction ablation and pacing for permanent atrial fibrillation. METHODS AND RESULTS Prospective randomized, single-blind, 3-month crossover comparison between RV and LV pacing (phase 1) and(More)
BACKGROUND Uncontrolled studies have suggested that atrioventricular junction ablation and pacemaker implantation have beneficial effects on quality of life in patients with chronic atrial fibrillation (AF). METHODS AND RESULTS We performed a multicenter, controlled, randomized, 12-month evaluation of the clinical effects of atrioventricular junction(More)
OBJECTIVE To evaluate the incidence and the strategy of management of syncope admitted urgently to a general hospital. BACKGROUND The management of patients with syncope is not standardized. METHODS The study was a prospective observational registry from a sample of 28 general hospitals in Italy and enroled all consecutive patients referred to their(More)
BACKGROUND In patients with syncope and structural heart disease, syncope is suspected to be attributable to a primary cardiac arrhythmia, but little is known of its mechanism when electrophysiologic study is unremarkable. METHODS AND RESULTS We applied an implantable loop recorder in 35 patients with overt heart disease at risk of ventricular arrhythmia,(More)
AIMS We prospectively correlated the results of tilt testing (TT) and adenosine triphosphate test (ATP) with the findings observed during a spontaneous syncopal relapse by means of an implantable loop recorder (ILR) in patients with a clinical diagnosis of neurally mediated syncope. METHODS AND RESULTS We included patients with three or more clinically(More)