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This paper introduces a novel architecture for implementing content-based pub/sub communications on top of structured overlay networks. This architecture overcomes some well-known limitations of existing infrastructures, i.e. lack of self-configuration and of adaptiveness to dynamic changes. This is achieved by devising a mediator stratum between the rich(More)
The Replication Logic is a set of protocols, mechanisms and services that allow a CORBA system to handle object replication. In this paper we present a specific implementation of a Replication Logic, namely Interoper-able Replication Logic (IRL), which exhibits nice properties like non-intrusion (i.e., the replication logic is built " above " the ORB) and(More)
In cooperative information systems, the quality of data exchanged and provided by different data sources is extremely important. A lack of attention to data quality can imply data of low quality to spread all over the cooperative system. At the same time, improvement can be based on comparing data, correcting them and thus disseminating high quality data.(More)
SUMMARY Enforcing strong replica consistency among a set of replicas of a service deployed across an asynchronous distributed system in the presence of crash failures is a real practical challenge. If each replica runs the consistency protocol bundled with the actual service implementation, this target cannot be achieved, as replicas need to be located over(More)
In this paper we present a performance evaluation of three Java group toolkits (JavaGroups, Spread and Appia) with respect to a specific application scenario: software replication using a three-tier architecture. We also compare performances of these Java group toolkits with Maestro/Ensemble which has been developed in C++. Results show that performances of(More)
Several efficient and very powerful algorithms exist for detecting changes in tree-based textual documents, such as those encoded in XML. An important aspect is still underestimated in their design and implementation: the quality of the output, in terms of readability, clearness and accuracy for human users. Such requirement is particularly relevant when(More)
ITF2357 (generic givinostat) is an orally active, hydroxamic-containing histone deacetylase (HDAC) inhibitor with broad anti-inflammatory properties, which has been used to treat children with systemic juvenile idiopathic arthritis. ITF2357 inhibits both Class I and II HDACs and reduces caspase-1 activity in human peripheral blood mononuclear cells and the(More)
BACKGROUND Maintaining physiological levels of hydrogen sulfide during ischemia is necessary to limit injury to the heart. Because of the anti-inflammatory effects of hydrogen sulfide, we proposed that the hydrogen sulfide donor, sodium sulfide (Na2S), would attenuate myocardial injury through upregulation of protective microRNA-21 (miR-21) and suppression(More)
Stem cells expressing c-kit have been identified in the adult epicardium. In mice, after myocardial infarction, these cells proliferate, migrate to the injury site and differentiate toward myocardial and vascular phenotype. We hypothesized that, acutely after myocardial infarction, pericardial sac integrity and pericardial fluid (PF) may play a role on(More)
The formation of the cryopyrin inflammasome in the heart induces an intense inflammatory response during acute myocardial infarction (AMI), which mediates further damage and promotes adverse cardiac remodelling. Active interleukin-1β (IL-1β) is a key product of the inflammasome, being cleaved by active caspase-1. The aim of this study was to dissect the(More)