Carlheinz R. Müller

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A number of HLA gene fragments have been reported and named. These are HLA-T previously known as HLA-16 (19), HLA-U previously known as HLA-21 (19), HLA-V previously known as HLA-75 (19), HLA-W previously known as HLA-80 (19), HLA-P previously known as HLA-90 (19) and HLA-Y previously known as HLA-BEL/COQ/DEL (20, 21). A full list of all recognised HLA(More)
Introduction In addition to thètestis determining factor' (SRY), the Y chromosome harbours genes important for spermatogenesis. Thèazoospermia factor' (AZF) on the long arm of the Y chromosome, originally de®ned by Tiepolo & Zuffardi (1976), is now progressively being dissected into discrete genes (Lahn & Page, 1997; Vogt et al., 1997). The deletion of the(More)
The WHO Nomenclature Committee for Factors of the HLA System met during the 15th International Histocompatibility and Immunogenetics Workshop in Buzios, Brazil in September 2008. This update is an extract of the main report that documents the additions and revisions to the nomenclature of human leukocyte antigen (HLA) specificities following the principles(More)
This project has the goal to validate bioinformatics methods and tools for HLA haplotype frequency analysis specifically addressing unique issues of haematopoietic stem cell registry data sets. In addition to generating new methods and tools for the analysis of registry data sets, the intent is to produce a comprehensive analysis of HLA data from 20 million(More)
The development of next-generation sequencing (NGS) technologies for HLA and KIR genotyping is rapidly advancing knowledge of genetic variation of these highly polymorphic loci. NGS genotyping is poised to replace older methods for clinical use, but standard methods for reporting and exchanging these new, high quality genotype data are needed. The(More)
Unrelated stem cell registries have been collecting HLA typing of volunteer bone marrow donors for over 25years. Donor selection for hematopoietic stem cell transplantation is based primarily on matching the alleles of donors and patients at five polymorphic HLA loci. As HLA typing technologies have continually advanced since the beginnings of stem cell(More)
The accuracy of human leukocyte antigen (HLA)-matching algorithms is a prerequisite for the correct and efficient identification of optimal unrelated donors for patients requiring hematopoietic stem cell transplantation. The goal of this World Marrow Donor Association study was to validate established matching algorithms from different international donor(More)
The degree of HLA concordance with the patient has long been known to be the major donor-related prediction factor for the success of hematopoietic stem cell transplantations and, with the progress of HLA typing technology, selection criteria became more stringent with regard to the recommended loci and resolution. A late refinement was HLA-C matching,(More)
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