Carla Truyers

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BACKGROUND Information on the incidence of serious infections in children in general practice is scarce. However, estimates on the incidence of disease are important for several reasons, for example to assess the burden of disease or as a basis of diagnostic research. We therefore estimated the incidence of serious infections in general practice in Belgium.(More)
BACKGROUND Computerized morbidity registration networks might serve as early warning systems in a time where natural epidemics such as the H1N1 flu can easily spread from one region to another. METHODS In this contribution we examine whether general practice based broad-spectrum computerized morbidity registration networks have the potential to act as a(More)
BACKGROUND Psychotic conditions and especially schizophrenia, have been associated with increased morbidity and mortality. Many studies are performed in specialized settings with a strong focus on schizophrenia. Somatic comorbidity after psychosis is studied, using a general practice comorbidity registration network. METHODS Hazard ratios are presented(More)
BACKGROUND Intego is the only operational computerized morbidity registration network in Belgium based on general practice data. Intego collects data from over 90 general practitioners. All the information is routinely collected in the electronic health record during daily practice. METHODS In this article we describe the design and methods used within(More)
BACKGROUND General Practitioners (GPs) play a central role in controlling an important risk factor for cardiovascular diseases, i.e. cholesterol levels in serum. In the past few decades different studies have been published on the effect of treating hyperlipidemia with statins. Guidelines for treatment have been adopted. We investigated the consequences on(More)
OBJECTIVES To picture the 10-year evolution of renal function in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) and to describe the risk factors for severe decline. SETTING Primary registration network with 97 general practitioners working in 55 practices sending routinely collected patient data. PARTICIPANTS From the(More)
BACKGROUND To date, there has been no comprehensive study on the association between atrial fibrillation (AF) and multimorbidity. The present study investigated the epidemiology of AF and the association between multimorbidity and the onset of AF. In addition, the correlation between multimorbidity and the use of anticoagulants and the risk of(More)
OBJECTIVES To examine the relation between static and dynamic blood pressure (BP) measurements and the evolution of kidney function in older people, adjusted for the presence of multimorbidity. DESIGN Retrospective cohort study during a 10-year time interval (2002-2012) in three age strata of patients aged 60 and older. SETTING Primary care registration(More)
BACKGROUND Simeprevir is a N3/4 protease inhibitor approved for the treatment of hepatitis C virus (HCV) infection. HCV prevalence is higher in patients with chronic kidney disease compared with the general population; safe and efficacious therapies in renal impairment are needed. OBJECTIVES To evaluate simeprevir renal excretion in healthy subjects and(More)
Ru(II)-arene complexes are promising alternatives for the clinically applied platinum-based chemotherapeutics. One approach is the attachment of bioactive molecules to organometallic moieties, leading to compounds with potential multi-targeted character which are able to interact with different biological targets [1,2]. [1,4]-Naphthoquinones are known for(More)
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