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Small molecule Toll-like receptor 7 agonists localize to the MHC class II loading compartment of human plasmacytoid dendritic cells.
TLR7 and TLR8 are intracellular sensors activated by single-stranded RNA species generated during viral infections. Various synthetic small molecules can also activate TLR7 or TLR8 or both through an… Expand
NAD-dependent ADP-ribosylation of the human antimicrobial and immune-modulatory peptide LL-37 by ADP-ribosyltransferase-1
- Monica Picchianti, Carla Russo, M. Castagnini, M. Biagini, E. Soldaini, E. Balducci
- Biology, Medicine
- Innate immunity
- 1 April 2015
LL-37 is a cationic peptide belonging to the cathelicidin family that has antimicrobial and immune-modulatory properties. Here we show that the mammalian mono-ADP-ribosyltransferase-1 (ART1), which… Expand
loading compartment of human plasmacytoid dendritic cells Small molecule Toll-like receptor 7 agonists localize to the MHC class II
doi:10.1182/blood-2010-12-328138Prepublished online April 12, 2011;2011 117: 5683-5691€€€€John Tallarico, Ennio De Gregorio and Elisabetta SoldainiIsome, Simona Tavarini, Chiara Sammicheli, Sandra… Expand